Treatment of acquired hemophilia A

被引:90
作者
Collins, P. W.
机构
[1] Univ Wales Hosp, Arthur Bloom Haemophilia Ctr, Cardiff, Wales
[2] Cardiff Univ, Cardiff, Wales
关键词
acquired hemophilia; bypassing agent; factor VIII; immunosuppression; inhibitor; FACTOR-VIII INHIBITORS; RECOMBINANT FACTOR-VIIA; PORCINE FACTOR-VIII; IMMUNOSUPPRESSIVE THERAPY; THROMBIN GENERATION; RANDOMIZED-TRIAL; NATURAL-HISTORY; UNITED-KINGDOM; POSTPARTUM; MANAGEMENT;
D O I
10.1111/j.1538-7836.2007.02433.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acquired hemophilia A (AH) is an autoimmune disease that leads to potentially severe bleeding. Management relies on rapid and accurate diagnosis, control of bleeding episodes and eradication of the inhibitor by immunosuppression. There is extensive literature about the disease but only few controlled data are available. This paper reviews the current literature on treatment strategies for hemostatic therapy and inhibitor eradication. Potential future developments are discussed.
引用
收藏
页码:893 / 900
页数:8
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