Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo

被引：17

作者：

Chathuranga, Kiramage ^{[1
]}

Weerawardhana, Asela ^{[1
]}

Dodantenna, Niranjan ^{[1
]}

Ranathunga, Lakmal ^{[1
]}

Cho, Won-Kyung ^{[2
]}

Ma, Jin Yeul ^{[2
]}

Lee, Jong-Soo ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea

[2] Korea Inst Oriental Med, Korean Med Applicat Ctr, Daegu 41062, South Korea

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Sargassum fusiforme; RSV; therapeutic effects; eicosane; docosane; tetracosane;

D O I：

10.3390/v13040548

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sargassum fusiforme, a plant used as a medicine and food, is regarded as a marine vegetable and health supplement to improve life expectancy. Here, we demonstrate that S. fusiforme extract (SFE) has antiviral effects against respiratory syncytial virus (RSV) in vitro and in vivo mouse model. Treatment of HEp2 cells with a non-cytotoxic concentration of SFE significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and syncytium formation. Moreover, oral inoculation of SFE significantly improved RSV clearance from the lungs of BALB/c mice. Interestingly, the phenolic compounds eicosane, docosane, and tetracosane were identified as active components of SFE. Treatment with a non-cytotoxic concentration of these three components elicited similar antiviral effects against RSV infection as SFE in vitro. Together, these results suggest that SFE and its potential components are a promising natural antiviral agent candidate against RSV infection.

引用

页数：14

共 55 条

[1] Antioxidant and antimicrobial activity evaluation and essential oil analysis of Semenovia tragioides Boiss. from Iran [J].