Racial Differences in S100b Levels in Persons with Schizophrenia

被引:10
作者
Gannon, Jessica M. [1 ,2 ]
Kelly, Deanna L. [3 ]
Besch, Abigail [1 ,2 ]
Thakur, Tanu [4 ]
Khurana, Neil [5 ]
Shurin, Michael R. [6 ]
Shurin, Galina, V [6 ]
Brar, Jaspreet S. [1 ]
Cihakova, Daniela [7 ]
Talor, Monica, V [7 ]
Chengappa, K. N. Roy [1 ,2 ]
机构
[1] Univ Pittsburgh, Western Psychiat Hosp, Med Ctr, 3811 OHara St, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, 3811 OHara St, Pittsburgh, PA 15213 USA
[3] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
[4] Inst Human Behav & Allied Sci, New Delhi, India
[5] Univ Pittsburgh, Med Ctr, 200 Lothrop St, Pittsburgh, PA 15213 USA
[6] Univ Pittsburgh, Dept Pathol, Med Ctr, 200 Lothrop St, Pittsburgh, PA 15213 USA
[7] Johns Hopkins Univ, Sch Med, Dept Pathol, Ross 659,720 Rutland Ave, Baltimore, MD 21210 USA
关键词
Schizophrenia; S100b; African-American; Caucasian; Inflammation; Race; NEURON-SPECIFIC ENOLASE; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; S-100; PROTEIN; SERUM;
D O I
10.1007/s11126-019-09687-4
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The calcium-binding protein S100b is secreted by glial cells in the brain and is also expressed by melanocytes. In nanomolar concentrations, S100b is considered to be a neurotrophic factor, but in micromolar concentrations, it is thought to reflect CNS injury and inflammation. Seen as a potential biomarker in traumatic brain injury, meta-analytic data from several studies report that S100b levels are significantly higher in persons with long standing schizophrenia, but also among first-episode patients compared to healthy control subjects. However, ethnic or racial differences are typically not mentioned when reporting levels of S100b. We assessed serum S100b levels in persons with schizophrenia (n = 136) who were participants in two independent research studies using the same enzyme-linked immunoassay (ELISA). African-American subjects had significantly higher levels of S100b (41.9 pg/ml +/- 62.2) than Caucasian subjects (24.9 pg/ml +/- 45.4) in the combined dataset (Mann-Whitney U = 1307, p < 0.001), as well as in each independent study. There were no significant differences in S100b levels between men and women. No significant correlations were observed between S100b levels and demographic or clinical variables. These data suggest that ethnicity or race should be given serious consideration when studying and interpreting S100b levels in persons with schizophrenia.
引用
收藏
页码:137 / 145
页数:9
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