The roles of triglyceride/high-density lipoprotein cholesterol ratio and uric acid as predisposing factors for metabolic syndrome in healthy children

被引:15
作者
Katsa, Maria Efthymia [1 ]
Ioannidis, Anastasios [1 ]
Sachlas, Athanasios [2 ]
Dimopoulos, Ioannis [3 ]
Chatzipanagiotou, Stylianos [4 ]
Gil, Andrea Paola Rojas [1 ]
机构
[1] Univ Peloponnese, Fac Hlth Sci, Dept Nursing, Tripolis, Greece
[2] Univ Piraeus, Fac Finance & Stat, Dept Stat & Insurance Sci, Athens, Greece
[3] Univ Peloponnese, Sch Management, Kalamata, Greece
[4] Kapodistrian Univ Athens, Med Sch, Aeginit Hosp, Dept Biopathol & Clin Microbiol, Athens, Greece
关键词
Triglyceride/high-density lipoprotein cholesterol ratio; Uric acid; Metabolic syndrome; Child; NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; ASSOCIATION; DISEASE; PREVALENCE; LEVEL; LDL; AGE;
D O I
10.6065/apem.2019.24.3.172
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: To estimate the roles of triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio and uric acid in predisposition for metabolic syndrome (MetS) and its components in healthy children. Methods: Anthropometric and biochemical analyses were performed on 110 children, aged 5 to 12 years, from the Greek county of Laconia. The children were studied as a whole population and in separate groups according to age and predisposition to MetS after taking into consideration International Diabetes Federation criteria, body mass index, and lipid profile. Results: Seventeen percent of children exhibited predisposition to MetS, while 39.1% had TG/HDL ratio >1, and 3.64% had high level of uric acid. According to a receiver operating characteristic curve analysis, the relative probability for MetS predisposition sextupled when TG/HDL ratio was >= 1 (odds ratio [OR], 5.986; 95% confidence interval [CI], 1.968-18.205). Children in the total population and those aged < 9 years had a greater probability for increased low-density lipoprotein (LDL) cholesterol (OR, 3.614; 95% CI, 1.561-8.365) when TG/HDL ratio was >= 1. The TG/HDL ratio was positively correlated with body mass index (BMI) (P=0.035) in children without MetS, cholesterol in the total population (P=0.06) and children >= 9 years old (P=0.026), and with LDL in the total population and both age groups (P=0.001). The TG/HDL ratio was also positively correlated with alanine aminotransferase in the total population (P=0.033) and gamma-glutamyl transferase in most studied groups (P<0.001). Uric acid was positively correlated with waist circumference in the total population (P=0.043) and in those without MetS (P=0.027). It was also positively correlated with BMI, TG, cholesterol, and TG/HDL ratio and negatively correlated with HDL in most studied groups (P<0.005). Conclusion: The studied parameters correlated with MetS components and could be characterized as effective indexes for childhood MetS, regardless of age and predisposition to MetS.
引用
收藏
页码:172 / 179
页数:8
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