A comparative genetic map of rat, mouse and human genomes

被引：65
作者：
Serikawa, T [1 ]
Cui, ZH
Yokoi, N
Kuramoto, T
Kondo, Y
Kitada, K
Guenet, JL
机构：
[1] Kyoto Univ, Fac Med, Inst Lab Anim, Sakyo Ku, Kyoto 60601, Japan
[2] Tanabe Seiyaku Co Ltd, Yodogawa Ku, Osaka 532, Japan
[3] Inst Pasteur, Unite Genet Mammiferes, F-75724 Paris, France
来源：
EXPERIMENTAL ANIMALS | 1998年 / 47卷 / 01期
关键词：
comparative genetic map; human; mouse; rat;
D O I：
10.1538/expanim.47.1
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The increasing availability of molecular markers and the development of highly efficient gene mapping strategies for the mouse, rat and human genomes have generated vast quantities of information allowing for the progressive refinement of comparative maps. In this publication we report on an updated Version of our rat/mouse/human comparative genetic map, based on the mouse map. Databases for mouse, rat and human gene mapping were used for the collection of homologs mapped in the species. The comparative map was constructed with a fetal of 1,235 mouse loci having known homologs in the rat and/or human: 16 having homologs only in the rat, 884 having only in the human and 335 both in the rat and human. The combined length of the segments conserved between the rat and mouse spans 758 cM on the mouse map. This indicates that about 47% of the mouse genome is now covered by known rat homologous regions. Five novel regions homologous for the rat and mouse were identified. This comparative genetic map should be useful for researchers working on genetic studies in the rat, mouse and human.
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页码：1 / 9
页数：9
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