Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea

被引：46
作者：
Aiello, Anna
Fattorusso, Ernesto
Giordano, Antonella
Menna, Marialuisa
Navarrete, Carmen
Munoz, Eduardo
机构：
[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[2] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba 14004, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 08期
关键词：
marine natural products; amino alcohols; cytotoxic compounds; ascidians;
D O I：
10.1016/j.bmc.2007.02.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A-F (1-6). Their stereo structures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：2920 / 2926
页数：7
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