The Oxygen Paradox, oxidative stress, and ageing

被引:26
作者
Davies, Kelvin J. A. [1 ,2 ]
机构
[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
[2] Univ So Calif, Div Mol & Computat Biol, Dept Biol Sci, Dornsife Coll Letters Arts & Sci, Los Angeles, CA 90089 USA
关键词
Oxidative stress; Ageing; Glutathione and glutathione peroxidase; Singlet oxygen; Peroxynitrite and nitric xide; Carotenoids; flavenols; and flavonoids; NITRIC-OXIDE; REVERSIBLE CONVERSION; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; ENDOTHELIAL-CELLS; SELENOPROTEIN-P; NITROXYL ANION; GLUTATHIONE; PLASMA; PROTECTS;
D O I
10.1016/j.abb.2015.11.015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Professor Helmut Sies is being lauded in this special issue of Archives of Biochemistry & Biophysics, on the occasion of his retirement as Editor-in-Chief. There is no doubt that Helmut has exerted an enormously positive influence on this journal, the fields of Biochemistry & Biophysics in general, and the areas of free radical and redox biology & medicine in particular. Helmut Sies' many discoveries about peroxide metabolism, glutathione, glutathione peroxidases, singlet oxygen, carotenoids in general and lycopene in particular, and flavonoids, fill the pages of his more than 600 publications. In addition, he will forever be remembered for coining the term 'oxidative stress' that is so widely used (and sometimes abused) by most of his colleagues. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:28 / 32
页数:5
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