Sodium Valproate-Induced Chromatin Remodeling

被引：32
作者：
Mello, Maria Luiza S. [1 ]
机构：
[1] Univ Campinas Unicamp, Dept Struct & Funct Biol, Campinas, Brazil
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金：
巴西圣保罗研究基金会;
关键词：
chromatin; sodium valproate; epigenetics; histones; DNA; image analysis; FTIR; HISTONE DEACETYLASE; TRANSCRIPTIONAL MEMORY; DNA DEMETHYLATION; ACID; METHYLATION; INHIBITION; CELLS; ANTICONVULSANT; MODULATION;
D O I：
10.3389/fcell.2021.645518
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of transcription factors, thus leading to modulation of gene expression. All these epigenetic changes have been associated with chromatin remodeling effects. The present minireview briefly reports the main effects of VPA on chromatin and image analysis and Fourier transform infrared (FTIR) microspectroscopy in association with molecular biology methodological approaches to investigate the VPA-induced changes in chromatin structure and at the higher-order supraorganizational level.
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页数：7
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