Death and anti-death: Tumour resistance to apoptosis

被引：1674

作者：

Igney, FH ^{[1
]}

Krammer, PH ^{[1
]}

机构：

[1] German Canc Res Ctr, Tumor Immunol Program, Heidelberg, Germany

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1038/nrc776

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?.

引用

页码：277 / 288

页数：12

共 181 条

[1] Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients [J].

Aas, T ;

Borresen, AL ;

Geisler, S ;

SmithSorensen, B ;

Johnsen, H ;

Varhaug, JE ;

Akslen, LA ;

Lonning, PE .

NATURE MEDICINE, 1996, 2 (07) :811-814

[2] Anti-apoptosis gene, survivin, and prognosis of neuroblastoma [J].

Adida, C ;

Berrebi, D ;

Peuchmaur, M ;

Reyes-Mugica, M ;

Altieri, DC .

LANCET, 1998, 351 (9106) :882-883

[3] A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J].

Ambrosini, G ;

Adida, C ;

Altieri, DC .

NATURE MEDICINE, 1997, 3 (08) :917-921

[4]

[Anonymous], CORRUPTION AND REFOR

[5]

Asgari K, 1997, INT J CANCER, V71, P377, DOI 10.1002/(SICI)1097-0215(19970502)71:3<377::AID-IJC13>3.3.CO

[6]

2-7

[7] Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice [J].

Bargou, RC ;

Wagener, C ;

Bommert, K ;

Mapara, MY ;

Daniel, PT ;

Arnold, W ;

Dietel, M ;

Guski, H ;

Feller, A ;

Royer, HD ;

Dorken, B .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (11) :2651-2659

[8] Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis [J].

Bennett, M ;

Macdonald, K ;

Chan, SW ;

Luzio, JP ;

Simari, R ;

Weissberg, P .

SCIENCE, 1998, 282 (5387) :290-293

[9] Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis [J].

Bertin, J ;

Armstrong, RC ;

Ottilie, S ;

Martin, DA ;

Wang, Y ;

Banks, S ;

Wang, GH ;

Senkevich, TG ;

Alnemri, ES ;

Moss, B ;

Lenardo, MJ ;

Tomaselli, KJ ;

Cohen, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1172-1176

[10] APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2 [J].

BISSONNETTE, RP ;

ECHEVERRI, F ;

MAHBOUBI, A ;

GREEN, DR .

NATURE, 1992, 359 (6395) :552-554

← 1 2 3 4 5 6 7 8 9 10 →