Contribution of stem cells and differentiated cells to epidermal tumours

被引：243
|
作者：
Owens, DM [1 ]
Watt, FM [1 ]
机构：
[1] Canc Res UK, London Res Inst, Keratinocyte Lab, London WC2A 3PX, England
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 06期
关键词：
D O I：
10.1038/nrc1096
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The outer covering of the skin-the epidermis-is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?.
引用
收藏
页码：444 / 451
页数：8
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