Synthesis, spectral characterization and DNA interactions of 5-(4-substituted phenyl)-1,3,4-thiadiazol-2-amine scaffolds

被引：13
|
作者：
Shivakumara, N. [1 ,2 ]
Krishna, P. Murali [1 ]
机构：
[1] MS Ramaiah Inst Technol, Dept Chem, Bengaluru 560054, India
[2] Visvesvaraya Technol Univ, Belagavi 590018, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1199卷
关键词：
Thiadiazoles; DNA binding; Fluorescence studies; Nuclease activity; ANTICONVULSANT ACTIVITY; SUBSTITUTED 1,3,4-THIADIAZOLES; MOLECULAR DOCKING; BINDING; DERIVATIVES; ANTAGONISTS; COMPLEXES; INSIGHTS; DESIGN; SERIES;
D O I：
10.1016/j.molstruc.2019.126999
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Five 5-(4-Substituted phenyl)-1, 3, 4-thiadiazole-2-amines have been prepared and structure of the compounds confirmed by spectroscopy studies. On the basis of spectroscopic studies, confirmed the formation of compounds. The DNA binding affinity of the prepared compounds was undertaken by absorption titration method and increasing the amount of CT-DNA observed hyperchromism or hypsochromism. The binding affinity compounds (except 5) are in the order of 4[13.341 x 10(4) M-1]>3 [8.505 x 10(4) M-1]>2 [3.567 x 10(4) M-1]>1[3.525 x 10(4) M-1]. The ethidiumbromide quenching results indicates CT-DNA was quenched by thiadiazoles via a static quenching mechanism. The DNA cleavage studies of the compounds were carried out in the presence and absence of H2O2 using gel electrophoresis experiment. (C) 2019 Elsevier B.V. All rights reserved.
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页数：9
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