Bioavailability of praziquantel increases with concomitant administration of food

被引：72
作者：
Castro, N
Medina, R
Sotelo, J
Jung, H
机构：
[1] Inst Nacl Neurol & Neurocirugia, Mexico City 14269, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期
关键词：
D O I：
10.1128/AAC.44.10.2903-2904.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.
引用
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页码：2903 / 2904
页数：2
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