Structure-Activity Relationship of s-Triazoles and Thiadiazoles as Analgesics

被引：4

作者：

Siwek, Agata ^{[1
]}

Wujec, Monika ^{[1
]}

Plech, Tomasz ^{[1
]}

Kusmierz, Edyta ^{[1
]}

Jagiello-Wojtowicz, Ewa ^{[2
]}

Chodkowska, Anna ^{[2
]}

机构：

[1] Med Univ, Fac Pharm, Dept Organ Chem, PL-20081 Lublin, Poland

[2] Med Univ, Fac Pharm, Dept Toxicol, PL-20093 Lublin, Poland

来源：

HETEROATOM CHEMISTRY | 2010年 / 21卷 / 04期

关键词：

PHARMACOLOGICAL-PROPERTIES; 1,3,4-THIADIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; ACETIC-ACID; 1,2,4-TRIAZOLE; PYRIMIDINE; AGENTS; DRUGS;

D O I：

10.1002/hc.20605

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The influence of s-triazoles (6-9) and thiadiazoles (10-11) on the central nervous system of mice in some behavioral tests was investigated. It was found that compounds (10) and (11) are the possible candidates for further development as analgesic agents. The correlation between the molecular descriptors and analgesic potential has been studied by using the pattern recognition methods: principal component analysis (PCA) and hierarchical cluster analysis (HCA). Our results, however, showed that the relationship between molecular descriptors and analgesic activity of s-triazoles and thiadiazoles cannot be easily explained on the basis of PCA and HCA. (C) 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:256-264, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20605

引用

页码：256 / 264

页数：9

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