An efficient catalytic deprotection of thioacetals employing bismuth triflate:: synthesis of pyrrolo[2,1-c] [1,4] benzodiazepines

被引：41

作者：

Kamal, A ^{[1
]}

Reddy, PSMM ^{[1
]}

Reddy, DR ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(03)00437-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient deprotection of thioacetals has been achieved by employing bismuth triflate. This method has been effectively employed in the preparation of DNA-binding pyrrolo[2,1-c] [1,4]benzodiazepine and its dimers. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2857 / 2860

页数：4

共 30 条

[1] [Anonymous], CHEM ARSENIC ANTIMON
[2] TOTAL SYNTHESIS OF (+-)-TRICHODERMIN
COLVIN, EW
RAPHAEL, RA
ROBERTS, JA
[J]. JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (15): : 858 - &
[3] COPPOLA GM, 1984, SYNTHESIS-STUTTGART, P1021
[4] OXIDATIVE HYDROLYSIS OF 1,3-DITHIANE DERIVATIVES TO CARBONYL COMPOUNDS USING N-HALOSUCCINIMIDE REAGENTS
COREY, EJ
ERICKSON, BW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (23) : 3553 - &
[5] ELLISON RA, 1975, TETRAHEDRON LETT, P499
[6] ALDEHYDES AND KETONES FROM THIOACETALS
FETIZON, M
JURION, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1972, (07) : 382 - &
[7] FIESER LF, 1969, REAGENTS ORGANIC SYN, V2, P182
[8] FIESER LF, 1967, REAGENTS ORGANIC SYN, V1, P654
[9] GREEN TW, 1999, PROTECTIVE GROUPS OR
[10] Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
Gregson, SJ
Howard, PW
Hartley, JA
Brooks, NA
Adams, LJ
Jenkins, TC
Kelland, LR
Thurston, DE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (05) : 737 - 748

← 1 2 3 →