Transport of organic anions by multidrug resistance-associated protein in the erythrocyte

被引：20

作者：

Rychlik, B ^{[1
]}

Pulaski, L ^{[1
]}

Sokal, A ^{[1
]}

Soszynski, M ^{[1
]}

Bartosz, G ^{[1
]}

机构：

[1] Univ Lodz, Dept Mol Biophys, PL-90237 Lodz, Poland

来源：

ACTA BIOCHIMICA POLONICA | 2000年 / 47卷 / 03期

关键词：

erythrocyte; transport; multidrug resistance-associate protein; glutathione; glutathione S-conjugates;

D O I：

10.18388/abp.2000_3994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The active transport of oxidized glutathione and glutathione S-conjugates has been demonstrated for the first time in erythrocytes and this cell remained the main subject of research on the "glutathione S-conjugate pump" for years. Further studies identified the "glutathione S-conjugate pump" as multidrug resistance-associated protein (MRP). Even though cells overexpressing MRP and isolated MRP provide useful information on MRP structure and function, the erythrocyte remains an interesting model cell for studies of MRP1 in its natural environment, including the substrate specificity and ATPase activity of the protein.

引用

收藏

页码：763 / 772

页数：10

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