Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3

被引：24
作者：
Brechenmacher, C
Larmet, Y
Feltz, P
Rodeau, JL
机构：
[1] CNRS, UPR 9009, Lab Neurobiol Cellulaire, F-67084 Strasbourg, France
[2] Univ Strasbourg 1, URA 1446, Lab Physiol Gen, F-67084 Strasbourg, France
来源：
NEUROSCIENCE LETTERS | 1998年 / 241卷 / 2-3期
关键词：
substance P; tachykinin receptors; sensory neurones; calcium; fura-2; capsaicin;
D O I：
10.1016/S0304-3940(98)00045-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The neuropeptide substance P (SP) is known to play a key role in peripheral nociceptive processes. We investigated the in vitro pharmacological characteristics of functional tachykinin receptors expressed in dorsal root ganglia (DRG) sensory neurones by analysing intracellular free calcium concentration changes induced after stimulation by SP or specific tachykinin agonists. We observed that about 37% of the tested neurones were responsive to either SP or an NK1-, NK2- or NK3-specific agonist. Tachykinin-responsive neurones had a small soma diameter (<20 mu m) and were sensitive to capsaicin. These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones. (C) 1998 Elsevier Science Ireland Ltd.
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收藏
页码：159 / 162
页数：4
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