Emerging roles of non-coding RNAs in vector-borne infections

被引:5
作者
Bensaoud, Chaima [1 ]
Martins, Larissa Almeida [1 ]
Aounallah, Hajer [2 ,3 ]
Hackenberg, Michael [4 ,5 ]
Kotsyfakis, Michail [1 ]
机构
[1] Czech Acad Sci, Biol Ctr, Inst Parasitol, Ceske Budejovice 37005, Budweis, Czech Republic
[2] Univ Tunis El Manar, Inst Pasteur Tunis, Serv Entomol Med, LR11IPT03, Tunis 1002, Tunisia
[3] Inst Butantan, Innovat & Dev Ctr, Innovat & Dev Lab, BR-05503900 Sao Paulo, Brazil
[4] Univ Granada, Fac Ciencias, Dept Genet, Campus Fuentenueva S-N, Granada 18071, Spain
[5] Inst Biotecnol, Ctr Invest Biomed, Lab Bioinformat, PTS, Avda Conocimiento S-N, Granada 18100, Spain
关键词
Non-coding RNAs; Vector-borne infection; Host-pathogen interactions; SUBGENOMIC FLAVIVIRUS RNA; HOST-PATHOGEN; LYME-DISEASE; VIRUS PATHOGENESIS; YERSINIA-PESTIS; III SECRETION; DNA; TRANSMISSION; CONTRIBUTES; BIOGENESIS;
D O I
10.1242/jcs.246744
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncRNAs encoded within the prokaryotic and eukaryotic genomes, leading to advances in several fields including parasitology. ncRNAs play major roles in several aspects of vector-host-pathogen interactions. Arthropod vector ncRNAs are secreted through extracellular vesicles into vertebrate hosts to counteract host defense systems and ensure arthropod survival. Conversely, hosts can use specific ncRNAs as one of several strategies to overcome arthropod vector invasion. In addition, pathogens transmitted through vector saliva into vertebrate hosts also possess ncRNAs thought to contribute to their pathogenicity. Recent studies have addressed ncRNAs in vectors or vertebrate hosts, with relatively few studies investigating the role of ncRNAs derived from pathogens and their involvement in establishing infections, especially in the context of vector-borne diseases. This Review summarizes recent data focusing on pathogen-derived ncRNAs and their role in modulating the cellular responses that favor pathogen survival in the vertebrate host and the arthropod vector, as well as host ncRNAs that interact with vector-borne pathogens.
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页数:10
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