Cytocompatible scaffolds of poly(L-lactide)/reduced graphene oxide for tissue engineering

被引：10
作者：
Diaz, Esperanza [1 ,2 ]
Iglesias, Naroa [1 ]
Ribeiro, Sylvie [3 ,4 ]
Lanceros-Mendez, Senentxu [2 ,5 ]
机构：
[1] Univ Pais Vasco UPV EHU, Escuela Ingn Bilbao, Dept Ingn Minera Met & Ciencia Mat, Portugalete 48920, Spain
[2] Basque Ctr Mat Applicat & Nanostruct, BCMat, UPV EHU Sci, Leioa, Spain
[3] Univ Minho, Ctr Fis, Braga, Portugal
[4] Univ Minho, Ctr Mol & Environm Biol CBMA, Braga, Portugal
[5] Ikerbasque, Basque Fdn Sci, Bilbao, Spain
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2021年 / 32卷 / 11期
关键词：
PLLA; rGO; hydrolysis; cytocompatible; bone regeneration; OSTEOGENIC DIFFERENTIATION; THERMAL-PROPERTIES; NANOCOMPOSITES; CRYSTALLIZATION; DEGRADATION; HYDROLYSIS;
D O I：
10.1080/09205063.2021.1922023
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Poly(L-lactide)/reduced graphene oxide (PLLA/rGO) scaffolds were studied in the present work. The scaffolds were fabricated by TIPS (thermally induced phase separation). Nonisothermal crystallization study for PLLA/rGO was investigated and revealed the nucleating effect of rGO. rGO effect on cytotoxicity, thermal properties, and hydrolysis resistance of PLLA and PLLA/rGO scaffolds were analysed. In vitro degradation in phosphate-buffered solution at 37 degrees C is analyzed over twelve weeks. A high crystalline behaviour reduces the speed of hydrolysis and therefore implies less variation in pH, mass loss and water up take. The rGO does not seem to accelerate the degradation process. Finally, rGO contents in PLLA up to 1 wt% dos not lead to cytotoxic effect, the scaffolds supporting cell adhesion and proliferation.
引用
收藏
页码：1406 / 1419
页数：14
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