Efficient siRNA delivery with non-cationic carriers

被引：27
作者：
Choi, Chun Kit K. [1 ]
Zhang, Lei [1 ]
Choi, Chung Hang Jonathan [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China
来源：
NATURE BIOMEDICAL ENGINEERING | 2018年 / 2卷 / 05期
关键词：
NANOPARTICLE;
D O I：
10.1038/s41551-018-0240-z
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Self-assembled weakly negative nanoparticles bearing an octet of short interfering RNAs, targeting ligands and endosomolytic peptides lead to efficient gene silencing in a mouse model of prostate cancer. © 2018 The Publisher.
引用
收藏
页码：275 / 276
页数：2
相关论文
共 14 条
[1]   Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles [J].
Davis, Mark E. ;
Zuckerman, Jonathan E. ;
Choi, Chung Hang J. ;
Seligson, David ;
Tolcher, Anthony ;
Alabi, Christopher A. ;
Yen, Yun ;
Heidel, Jeremy D. ;
Ribas, Antoni .
NATURE, 2010, 464 (7291) :1067-U140
[2]   A Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy [J].
Ding, Fei ;
Mou, Quanbing ;
Ma, Yuan ;
Pan, Gaifang ;
Guo, Yuanyuan ;
Tong, Gangsheng ;
Choi, Chung Hang Jonathan ;
Zhu, Xinyuan ;
Zhang, Chuan .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (12) :3064-3068
[3]   Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape [J].
Gilleron, Jerome ;
Querbes, William ;
Zeigerer, Anja ;
Borodovsky, Anna ;
Marsico, Giovanni ;
Schubert, Undine ;
Manygoats, Kevin ;
Seifert, Sarah ;
Andree, Cordula ;
Stoeter, Martin ;
Epstein-Barash, Hila ;
Zhang, Ligang ;
Koteliansky, Victor ;
Fitzgerald, Kevin ;
Fava, Eugenio ;
Bickle, Marc ;
Kalaidzidis, Yannis ;
Akinc, Akin ;
Maier, Martin ;
Zerial, Marino .
NATURE BIOTECHNOLOGY, 2013, 31 (07) :638-U102
[4]  
Jensen S.A., 2013, Sci. Transl. Med, V5, p209ra152
[5]  
Lee H, 2012, NAT NANOTECHNOL, V7, P389, DOI [10.1038/NNANO.2012.73, 10.1038/nnano.2012.73]
[6]   RNA interference in the clinic: challenges and future directions [J].
Pecot, Chad V. ;
Calin, George A. ;
Coleman, Robert L. ;
Lopez-Berestein, Gabriel ;
Sood, Anil K. .
NATURE REVIEWS CANCER, 2011, 11 (01) :59-67
[7]   Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression [J].
Pi, Fengmei ;
Binzel, Daniel W. ;
Lee, Tae Jin ;
Li, Zhefeng ;
Sun, Meiyan ;
Rychahou, Piotr ;
Li, Hui ;
Haque, Farzin ;
Wang, Shaoying ;
Croce, Carlo M. ;
Guo, Bin ;
Evers, B. Mark ;
Guo, Peixuan .
NATURE NANOTECHNOLOGY, 2018, 13 (01) :82-+
[8]   Biotechnological mass production of DNA origami [J].
Praetorius, Florian ;
Kick, Benjamin ;
Behler, Karl L. ;
Honemann, Maximilian N. ;
Weuster-Botz, Dirk ;
Dietz, Hendrik .
NATURE, 2017, 552 (7683) :84-+
[9]   Cancer nanomedicine: progress, challenges and opportunities [J].
Shi, Jinjun ;
Kantoff, Philip W. ;
Wooster, Richard ;
Farokhzad, Omid C. .
NATURE REVIEWS CANCER, 2017, 17 (01) :20-37
[10]   A ribonucleoprotein octamer for targeted siRNA delivery [J].
Tai, Wanyi ;
Li, Junwei ;
Corey, Eva ;
Gao, Xiaohu .
NATURE BIOMEDICAL ENGINEERING, 2018, 2 (05) :326-337
12