Regulated nucleosome mobility and the histone code

被引：270
作者：
Cosgrove, MS
Boeke, JD
Wolberger, C
机构：
[1] Johns Hopkins Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA
[2] Johns Hopkins Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA
[3] Johns Hopkins Sch Med, High Throughput Ctr, Baltimore, MD 21205 USA
[4] Johns Hopkins Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nsmb851
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.
引用
收藏
页码：1037 / 1043
页数：7
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