Small-molecule caspase inhibitors

被引：7

作者：

Zhenodarova, S. M. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

来源：

RUSSIAN CHEMICAL REVIEWS | 2010年 / 79卷 / 02期

基金：

英国经济与社会研究理事会; 英国医学研究理事会;

关键词：

SELECTIVE NONPEPTIDE INHIBITORS; STRUCTURE-BASED DESIGN; SULFONAMIDE ANALOGS; ACYL DIPEPTIDES; ALLOSTERIC SITE; CELL-GROWTH; POTENT; DISCOVERY; APOPTOSIS; IDENTIFICATION;

D O I：

10.1070/RC2010v079n02ABEH004056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

There view considers low-molecular weight inhibitors of caspases, cysteine proteases being key contributors to apoptosis (programmed cell death). The inhibitors with aspartic acid residues or various heterocyclic systems (both synthetic and natural) are covered. Their possible mechanisms of action are discussed. Data on inhibitor structure-activity relationship studies are systematically surveyed. The interactions of the non-peptide fragments of an inhibitor with the enzymes are examined. Examples of the use of some inhibitors for apoptosis suppression are provided. The bibliography includes 60 references.

引用

页码：119 / 143

页数：25

共 60 条

[1] Identification of potent and novel small-molecule inhibitors of caspase-3 [J].

Allen, DA ;

Pham, P ;

Choong, IC ;

Fahr, B ;

Burdett, MT ;

Lew, W ;

DeLano, WL ;

Gordon, EM ;

Lam, JW ;

O'Brien, T ;

Lee, D .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (21) :3651-3655

[2] Reducing the peptidyl features of caspase-3 inhibitors: A structural analysis [J].

Becker, JW ;

Rotonda, J ;

Soisson, SM ;

Aspiotis, R ;

Bayly, C ;

Francoeur, S ;

Gallant, M ;

Garcia-Calvo, M ;

Giroux, A ;

Grimm, E ;

Han, YX ;

McKay, D ;

Nicholson, DW ;

Peterson, E ;

Renaud, J ;

Roy, S ;

Thornberry, N ;

Zamboni, R .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) :2466-2474

[3] A Novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury [J].

Chapman, JG ;

Magee, WP ;

Stukenbrok, HA ;

Beckius, GE ;

Milici, AJ ;

Tracey, WR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 456 (1-3) :59-68

[4] Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors [J].

Chen, YH ;

Zhang, YH ;

Zhang, HJ ;

Liu, DZ ;

Gu, M ;

Li, JY ;

Wu, F ;

Zhu, XZ ;

Li, J ;

Nan, F .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (05) :1613-1623

[5]

Chen YQ, 1999, CANCER RES, V59, P3985

[6] Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design [J].

Choong, IC ;

Lew, W ;

Lee, D ;

Pham, P ;

Burdett, MT ;

Lam, JW ;

Wiesmann, C ;

Luong, TN ;

Fahr, B ;

DeLano, WL ;

McDowell, RS ;

Allen, DA ;

Erlanson, DA ;

Gordon, EM ;

O'Brien, T .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (23) :5005-5022

[7] Isatin sulfonamide analogs containing a michael addition acceptor: A new class of caspase 3/7 inhibitors [J].

Chu, Wenhua ;

Rothfuss, Justin ;

d'Avignon, Andre ;

Zeng, Chenbo ;

Zhou, Dong ;

Hotchkiss, Richard S. ;

Mach, Robert H. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (15) :3751-3755

[8] N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors:: Synthesis, in vitro activity, and molecular modeling studies [J].

Chu, WH ;

Zhang, J ;

Zeng, CB ;

Rothfuss, J ;

Tu, ZD ;

Chu, YX ;

Reichert, DE ;

Welch, MJ ;

Mach, RH .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (24) :7637-7647

[9] Caspases: Keys in the ignition of cell death [J].

Denault, JB ;

Salvesen, GS .

CHEMICAL REVIEWS, 2002, 102 (12) :4489-4499

[10] Peptide exosite inhibitors of factor VIIa as anticoagulants [J].

Dennis, MS ;

Eigenbrot, C ;

Skelton, NJ ;

Ultsch, MH ;

Santell, L ;

Dwyer, MA ;

O'Connell, MP ;

Lazarus, RA .

NATURE, 2000, 404 (6777) :465-470

← 1 2 3 4 5 6 →