Less fat with nesfatin

被引：17
作者：
Colmers, William F. [1 ]
机构：
[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2007年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.tem.2007.02.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The brain receives information on the body's fuel supply through a bewildering array of chemical messengers that signal either negative or positive energy balance. Nesfatin-1, a secreted protein of previously unknown function, acts as a satiety factor. Nesfatin-1 suppresses appetite in both the short term and the long term, is made by neurons in brain centers that regulate energy balance and might act via melanocortin pathways. Nesfatin-1 is the latest addition to the surprisingly large number of chemical messengers telling the body that the tank is full.
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收藏
页码：131 / 132
页数：2
相关论文
共 10 条
  • [1] Studies on the physiological functions of the melanocortin system
    Cone, Roger D.
    [J]. ENDOCRINE REVIEWS, 2006, 27 (07) : 736 - 749
  • [2] The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Cowley, MA
    Smith, RG
    Diano, S
    Tschöp, M
    Pronchuk, N
    Grove, KL
    Strasburger, CJ
    Bidlingmaier, M
    Esterman, M
    Heiman, ML
    Garcia-Segura, LM
    Nillni, EA
    Mendez, P
    Low, MJ
    Sotonyi, P
    Friedman, JM
    Liu, HY
    Pinto, S
    Colmers, WF
    Cone, RD
    Horvath, TL
    [J]. NEURON, 2003, 37 (04) : 649 - 661
  • [3] Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    Cowley, MA
    Smart, JL
    Rubinstein, M
    Cordán, MG
    Diano, S
    Horvath, TL
    Cone, RD
    Low, MJ
    [J]. NATURE, 2001, 411 (6836) : 480 - 484
  • [4] Gastrointestinal regulation of food intake
    Cummings, David E.
    Overduin, Joost
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) : 13 - 23
  • [5] Elias CF, 2000, J COMP NEUROL, V423, P261
  • [6] Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    Fan, W
    Boston, BA
    Kesterson, RA
    Hruby, VJ
    Cone, RD
    [J]. NATURE, 1997, 385 (6612) : 165 - 168
  • [7] Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    Huszar, D
    Lynch, CA
    FairchildHuntress, V
    Dunmore, JH
    Fang, Q
    Berkemeier, LR
    Gu, W
    Kesterson, RA
    Boston, BA
    Cone, RD
    Smith, FJ
    Campfield, LA
    Burn, P
    Lee, F
    [J]. CELL, 1997, 88 (01) : 131 - 141
  • [8] Li SJ, 1996, J NEUROSCI, V16, P5182
  • [9] Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    Oh-, Shinsuke, I
    Shimizu, Hiroyuki
    Satoh, Tetsurou
    Okada, Shuichi
    Adachi, Sachika
    Inoue, Kinji
    Eguchi, Hiroshi
    Yamamoto, Masanori
    Imaki, Toshihiro
    Hashimoto, Koushi
    Tsuchiya, Takafumi
    Monden, Tsuyoshi
    Horiguchi, Kazuhiko
    Yamada, Masanobu
    Mori, Masatomo
    [J]. NATURE, 2006, 443 (7112) : 709 - 712
  • [10] Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion
    Thiele, TE
    Van Dijk, G
    Yagaloff, KA
    Fisher, SL
    Schwartz, M
    Burn, P
    Seeley, RJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (01) : R248 - R254
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