(D2O-H2O) solvent isotope effects on some thermodynamic properties of the Albicar dissolution (hydration) between T = (278.15 and 313.15) K at ambient pressure

被引：5

作者：

Ivanov, Evgeniy V. ^{[1
]}

Batov, Dmitriy V. ^{[2
,3
]}

Kravchenko, Angelina N. ^{[4
]}

机构：

[1] Russian Acad Sci, GA Krestov Inst Solut Chem, Lab Thermodynam Solut Nonelectrolytes & Biol Act, 1 Akad Skaya Str, Ivanovo 153045, Russia

[2] Russian Acad Sci, GA Krestov Inst Solut Chem, Inc Physicochem Ctr Solut Res, 1 Akad Skaya Str, Ivanovo 153045, Russia

[3] Ivanovos State Univ Chem & Technol, Dept Inorgan Chem, 7 Sheremetevsky Ave, Ivanovo 153000, Russia

[4] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Lab Nitrogen Containing Cpds, 47 Leninsky Ave, Moscow 199119, Russia

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2016年 / 97卷

关键词：

Enthalpies of solution; Albicar; Ordinary and heavy water; BIS-UREA MEBICARUM; AQUEOUS-SOLUTIONS; INTERMOLECULAR INTERACTIONS; HEAVY-WATER; MOLAR VOLUMES; ENTHALPIES; SOLVATION; MIXTURES; APPARENT; TEMPERATURES;

D O I：

10.1016/j.jct.2016.02.012

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The molar enthalpies of solution of a drug Albicar or 1,4-diethyl-3,6-dimethyltetrahydroimidazo[4,5-d]imidazole-2,5(1H, 3H)-dione in ordinary (H2O) and heavy (D2O) water at T = (278.15, 279.15, 288.15, 298.15, 308.15, and 313.15) K and ambient pressure were measured calorimetrically. The standard (at infinite dilution) molar enthalpies and heat capacities of the solute dissolution along with the (D2O-H2O) solvent isotope effects (IEs) on the specified quantities were computed. The enthalpic effects of Albicar dissolution in H2O and D2O experience a negative-to-positive sign inversion nearby T-inv = (306 and 307) K, respectively, whereas the corresponding IEs were found to be wholly negative (by sign) and decreasing in magnitude with increasing temperature. These facts indicate that the Albicar hydration, being dualistic (hydrophobic-hydrophilic) in nature, is enhanced in the D2O medium. The hydration behavior of the studied solute was discussed in comparison with those for Mebicar (1,3,4,6-tetramethyl-derivative) and Bicaret (1,3,4,6-tetraethyl-derivative) using the previously obtained data. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：341 / 347

页数：7

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