The harmful effect of indoxyl sulfate on neovascularization in chronic kidney disease

被引：12
作者：
Dou, Laetitia [1 ]
Burtey, Stephane [1 ,2 ]
机构：
[1] Aix Marseille Univ, INSERM, Vasc Res Ctr Marseille, UMR S 1076, F-13005 Marseille, France
[2] Ctr Nephrol Dialyse Transplantat Renale, CHU Concept, Assistance Publ Hop Marseille, Marseille, France
来源：
KIDNEY INTERNATIONAL | 2016年 / 89卷 / 03期
关键词：
ARTERY-DISEASE; UREMIC TOXINS; INJURY; CKD;
D O I：
10.1016/j.kint.2015.12.030
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with chronic kidney disease display an impairment of neovascularization in ischemic tissues. Studies have suggested the involvement of the uremic toxin indoxyl sulfate by demonstrating that indoxyl sulfate affects endothelial progenitor cells. However, few data are available on the effects of indoxyl sulfate on neovascularization and on the mechanisms involved. The article by Hung et al. shows that indoxyl sulfate suppresses neovascularization in uremic mice by impairing endothelial progenitor cell function via the inhibition of hypoxia-induced hypoxia-inducible factor/interleukin-10/vascular endothelial growth factor signaling. (C) 2016 International Society of Nephrology
引用
收藏
页码：532 / 534
页数：3
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