Japonicones E-L, Dimeric Sesquiterpene Lactones from Inula japonica Thunb.

被引：56

作者：

Qin, Jiang Jiang ^{[1
]}

Jin, Hui Zi ^{[1
]}

Zhu, Jia Xian ^{[1
]}

Fu, Jian Jun ^{[1
]}

Hu, Xiao Jia ^{[1
]}

Liu, Xiao Hua ^{[2
]}

Zhu, Yan ^{[1
]}

Yan, Shi Kai ^{[1
]}

Zhang, Wei Dong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Second Mil Med Univ, Dept Phytochem, Shanghai, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 03期

基金：

中国博士后科学基金;

关键词：

japonicones E-L; sesquiterpene dimmer; Inula japonica Thunb; Asteraceae; NO production; CONSTITUENTS; BRITANNICA;

D O I：

10.1055/s-0029-1186065

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new dimeric sesquiterpene lactones (japonicones E-L, 1-8), including a novel sesquiterpene dimer bearing a rare hydroperoxide group (japonicone E, 1), were isolated from the aerial part of Inula japonica Thunb. Their structures were determined mainly by the use of 1D and 2D NMR spectroscopic techniques including HSQC, H-1-H-1 COSY, HMBC, and NOESY. All the isolates were tested for inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among the compounds tested, japonicone F (2) showed the strongest activity with the IC50 value of 4.1 mu g/mL.

引用

页码：278 / 283

页数：6

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