A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest

被引：3

作者：

Lee, Dae Hyun ^{[1
]}

Money, David B. ^{[2
]}

Deshpande, Akshay ^{[2
]}

Samuels, Brian ^{[3
]}

机构：

[1] Univ S Florida, Cardiol, Tampa, FL 33620 USA

[2] Univ S Florida, Internal Med, Tampa, FL 33620 USA

[3] Univ S Florida, Emergency Med, Tampa, FL 33620 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 03期

关键词：

hypokalemia; cardiotoxicity; cardio-oncology; torsades de pointes; abiraterone; ACETATE;

D O I：

10.7759/cureus.23678

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiraterone-related hypokalemia which led to torsades de pointes (TdP) and ventricular fibrillation (VF). We reviewed the literature and showed the need for close monitoring of the potassium level and electrocardiogram (ECG) to prevent fatal arrhythmias.

引用

页数：4

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