A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest

被引：4
作者：
Lee, Dae Hyun [1 ]
Money, David B. [2 ]
Deshpande, Akshay [2 ]
Samuels, Brian [3 ]
机构：
[1] Univ S Florida, Cardiol, Tampa, FL 33620 USA
[2] Univ S Florida, Internal Med, Tampa, FL 33620 USA
[3] Univ S Florida, Emergency Med, Tampa, FL 33620 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 03期
关键词：
hypokalemia; cardiotoxicity; cardio-oncology; torsades de pointes; abiraterone; ACETATE;
D O I：
10.7759/cureus.23678
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiraterone-related hypokalemia which led to torsades de pointes (TdP) and ventricular fibrillation (VF). We reviewed the literature and showed the need for close monitoring of the potassium level and electrocardiogram (ECG) to prevent fatal arrhythmias.
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页数：4
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共 14 条
  • [1] Cardiac arrhythmia considerations of hormone cancer therapies
    Barber, Mary
    Nguyen, Lee S.
    Wassermann, Johanna
    Spano, Jean-Philippe
    Funck-Brentano, Christian
    Salem, Joe-Elie
    [J]. CARDIOVASCULAR RESEARCH, 2019, 115 (05) : 878 - 894
  • [2] Abiraterone acetate plus prednisone in patients with newly Croatia& diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial
    Fizazi, Karim
    NamPhuong Tran
    Fein, Luis
    Matsubara, Nobuaki
    Rodriguez-Antolin, Alfredo
    Alekseev, Boris Y.
    Ozguroglu, Mustafa
    Ye, Dingwei
    Feyerabend, Susan
    Protheroe, Andrew
    Sulur, Giri
    Luna, Yesenia
    Li, Susan
    Mundle, Suneel
    Chi, Kim N.
    [J]. LANCET ONCOLOGY, 2019, 20 (05) : 686 - 700
  • [3] Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
    Fizazi, Karim
    Scher, Howard I.
    Molina, Arturo
    Logothetis, Christopher J.
    Chi, Kim N.
    Jones, Robert J.
    Staffurth, John N.
    North, Scott
    Vogelzang, Nicholas J.
    Saad, Fred
    Mainwaring, Paul
    Harland, Stephen
    Goodman, Oscar B., Jr.
    Sternberg, Cora N.
    Li, Jin Hui
    Kheoh, Thian
    Haqq, Christopher M.
    de Bono, Johann S.
    [J]. LANCET ONCOLOGY, 2012, 13 (10) : 983 - 992
  • [4] Khan A, 2016, NEW ZEAL MED J, V129, P124
  • [5] Mechanisms of hypokalemia-induced ventricular arrhythmogenicity
    Osadchii, Oleg E.
    [J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2010, 24 (05) : 547 - 559
  • [6] Abiraterone Acetate-Induced Life-Threatening Torsade de Pointes
    Rodieux, Frederique
    Nieto, Nathalie
    Sunthorn, Henri
    John, Gregor
    Escher, Monica
    [J]. ANNALS OF PHARMACOTHERAPY, 2015, 49 (01) : 152 - 153
  • [7] Clinical characterization of men with long QT syndrome and torsades de pointes associated with hypogonadism: A review and pharmacovigilance study
    Salem, Joe-Elie
    Bretagne, Marie
    Lebrun-Vignes, Benedicte
    Waintraub, Xavier
    Gandjbakhch, Estelle
    Hidden-Lucet, Francoise
    Gougis, Paul
    Bachelot, Anne
    Funck-Brentano, Christian
    [J]. ARCHIVES OF CARDIOVASCULAR DISEASES, 2019, 112 (11) : 699 - 712
  • [8] Androgenic Effects on Ventricular Repolarization A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes
    Salem, Joe-Elie
    Yang, Tao
    Moslehi, Javid J.
    Waintraub, Xavier
    Gandjbakhch, Estelle
    Bachelot, Anne
    Hidden-Lucet, Francoise
    Hulot, Jean-Sebastien
    Knollmann, Bjorn C.
    Lebrun-Vignes, Benedicte
    Funck-Brentano, Christian
    Glazer, Andrew M.
    Roden, Dan M.
    [J]. CIRCULATION, 2019, 140 (13) : 1070 - 1080
  • [9] Hypogonadism as a Reversible Cause of Torsades de Pointes in Men
    Salem, Joe-Elie
    Waintraub, Xavier
    Courtillot, Carine
    Shaffer, Christian M.
    Gandjbakhch, Estelle
    Maupain, Carole
    Moslehi, Javid J.
    Badilini, Fabio
    Haroche, Julien
    Gougis, Paul
    Fressart, Veronique
    Glazer, Andrew M.
    Hidden-Lucet, Francoise
    Touraine, Philippe
    Lebrun-Vignes, Benedicte
    Roden, Dan M.
    Bachelot, Anne
    Funck-Brentano, Christian
    [J]. CIRCULATION, 2018, 138 (01) : 110 - 113
  • [10] Schimmer BP., 2011, Goodman and Gillman's The Pharmacological Basis of Therapeutics, V12th, P1209
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