Functional expression of a mammalian odorant receptor

被引:486
作者
Zhao, HQ
Ivic, L
Otaki, JM
Hashimoto, M
Mikoshiba, K
Firestein, S [1 ]
机构
[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
[2] Yale Univ, Interdept Neurosci Program, New Haven, CT 06510 USA
[3] RIKEN, Tsukuba Life Sci Ctr, Mol Neurobiol Lab, Tsukuba, Ibaraki 305, Japan
关键词
D O I
10.1126/science.279.5348.237
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.
引用
收藏
页码:237 / 242
页数:6
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