The endocytic matrix

被引：371

作者：

Scita, Giorgio ^{[1
,2
]}

Di Fiore, Pier Paolo ^{[1
,2
,3
]}

机构：

[1] FIRC Inst Mol Oncol Fdn, IFOM, I-20139 Milan, Italy

[2] Univ Milan, Dept Med Surg & Dent, I-20122 Milan, Italy

[3] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

来源：

NATURE | 2010年 / 463卷 / 7280期

基金：

欧洲研究理事会;

关键词：

ASYMMETRIC CELL-DIVISION; TGF-BETA RECEPTOR; ANCHORED GROWTH-FACTOR; CLATHRIN HEAVY-CHAIN; FYVE DOMAIN PROTEIN; P53-MEDIATED TRANSCRIPTION; ENDOSOMAL COMPARTMENT; ALPHA-ADAPTIN; MAP KINASE; STEM-CELLS;

D O I：

10.1038/nature08910

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its main roles being the resolution of signals in space and time. Many of the functions of endocytosis that are emerging from recent research cannot yet be reconciled with the canonical view of intracellular trafficking but, instead, point to endocytosis being integrated at a deeper level in the cellular 'master plan' (the cellular network of signalling circuits that lie at the base of the cell's make-up). Deconvolution of this level, which we call the 'endocytic matrix', might uncover a fundamental aspect of how a cell is built.

引用

页码：464 / 473

页数：10

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