Diagnostic Approach to Traumatic Axonal Injury of the Spinothalamic Tract in Individual Patients with Mild Traumatic Brain Injury

被引:8
作者
Jang, Sung Ho [1 ]
Lee, Han Do [2 ]
机构
[1] Yeungnam Univ, Coll Med, Dept Phys Med & Rehabil, HyunChungro 170, Daegu 705717, South Korea
[2] Ulsan Coll Univ, Coll Nat Sci, Dept Phys Therapy, Bongsuro 101 Dongku, Ulsan 44022, South Korea
基金
新加坡国家研究基金会;
关键词
Spinothalamic tract; Mild traumatic brain injury; Traumatic axonal injury; Diffusion tensor tractography; NEUROPATHIC PAIN; PATHOPHYSIOLOGY; TRACTOGRAPHY; MECHANISMS;
D O I
10.3390/diagnostics9040199
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: We investigated an approach for the diagnosis of traumatic axonal injury (TAI) of the spinothalamic tract (STT) that was based on diffusion tensor tractography (DTT) results and a statistical comparison of individual patients who showed central pain following mild traumatic brain injury (mTBI) with the control group. Methods: Five right-handed female patients in their forties and with central pain following mTBI and 12 age-, sex-, and handedness-matched healthy control subjects were recruited. After DTT reconstruction of the STT, we analyzed the STT in terms of three DTT parameters (fractional anisotropy (FA), mean diffusivity (MD), and fiber number (FN)) and its configuration (narrowing and tearing). To assess narrowing, we determined the area of the STT on an axial slice of the subcortical white matter. Results: the FN values were significantly lower in at least one hemisphere of each patient when compared to those of the control subjects (p < 0.05). Significant decrements from the STT area in the control group were observed in at least one hemisphere of each patient (p < 0.05). Regarding configurational analysis, the STT showed narrowing and/or partial tearing in at least one hemisphere of each of the five patients. Conclusions: Herein, we demonstrate a DTT-based approach for the diagnosis of TAI of the STT. The approach involves a statistical comparison between DTT parameters of individual patients who show central pain following mTBI and those of an age-, gender-, and handedness-matched control group. We think that the method described in this study can be useful in the diagnosis of TAI of the STT in individual mTBI patients.
引用
收藏
页数:7
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