Chronic hepatitis B and non-alcoholic fatty liver disease: Conspirators or competitors?

被引：65
作者：
Zhang, Jianbin [1 ]
Lin, Shuangzhe [1 ]
Jiang, Daixi [1 ]
Li, Mengting [2 ]
Chen, Yuanwen [1 ]
Li, Jun [3 ]
Fan, Jiangao [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
[2] Yinzhou Peoples Hosp, Dept Gastroenterol, Ningbo, Zhejiang, Peoples R China
[3] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Sch Med,Affiliated Hosp 1, Hangzhou, Peoples R China
来源：
LIVER INTERNATIONAL | 2020年 / 40卷 / 03期
基金：
中国国家自然科学基金;
关键词：
animal model; chronic hepatitis B; genetic susceptibility; innate immunity; metabolism; non-alcoholic fatty liver disease; VIRUS-X PROTEIN; ALANINE AMINOTRANSFERASE LEVELS; BODY-MASS INDEX; HBSAG SEROCLEARANCE; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; SURFACE-ANTIGEN; METABOLIC SYNDROME; GENOTYPE B; VIRAL LOAD;
D O I：
10.1111/liv.14369
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Despite the widespread use of vaccines and antiviral drugs, approximately 350-400 million patients with chronic hepatitis B (CHB) remain worldwide, who carry high risk of cirrhosis and liver carcinoma. Moreover, owing to improvements in global living standards and lifestyle changes, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease. Coexistence of NAFLD and CHB is commonly observed, especially in Asian CHB populations; however, little is known regarding the relationship between these two diseases as comorbidities. In this review, we summarize recent advances in clinical and basic researches related to the underlying mutual interactions, as well as potential animal models to facilitate further investigation.
引用
收藏
页码：496 / 508
页数：13
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