Diagnostic and Prognostic Value of the Combination of Two Measures of Verbal Memory in Mild Cognitive Impairment due to Alzheimer's Disease

被引:25
作者
Sala, Isabel [1 ,3 ]
Illan-Gala, Ignacio [1 ,3 ]
Alcolea, Daniel [1 ,3 ]
Belen Sanchez-Saudinos, Ma [1 ,3 ]
Andres Salgado, Sergio [1 ]
Morenas-Rodriguez, Estrella [1 ,3 ]
Subirana, Andrea [1 ,3 ]
Videla, Laura [1 ,2 ,3 ]
Clarimon, Jordi [1 ,3 ]
Carmona-Iragui, Maria [1 ,2 ,3 ]
Ribosa-Nogue, Roser [1 ,3 ]
Blesa, Rafael [1 ,3 ]
Fortea, Juan [1 ,2 ,3 ]
Lleo, Alberto [1 ,3 ]
机构
[1] Univ Autonoma Barcelona, Memory Unit, Dept Neurol, Hosp Santa Creu & St Pau,Biomed Res Inst St Pau, Barcelona, Spain
[2] Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
[3] CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
关键词
Alzheimer's disease; biomarkers; cerebrospinal fluid; episodic memory; mild cognitive impairment; mild neurocognitive disorder; neuropsychological test; CEREBROSPINAL-FLUID BIOMARKERS; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; BEHAVIORAL VARIANT; AMNESTIC SYNDROME; CRITERIA; RECOMMENDATIONS; GUIDELINES; INFLAMMATION; PREDICTION;
D O I
10.3233/JAD-170073
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Episodic memory impairment is the core feature of typical Alzheimer's disease. Objective: To evaluate the performance of two commonly used verbal memory tests to detect mild cognitive impairment due to Alzheimer's disease (MCI-AD) and to predict progression to Alzheimer's disease dementia (AD-d). Methods: Prospective study of MCI patients in a tertiary memory disorder unit. Patients underwent an extensive neuropsychological battery including two tests of declarative verbal memory: The Free and Cued Selective Reminding Test (FCSRT) and the word list learning task from the Consortium to Establish a Registry for Alzheimer's disease (CERAD-WL). Cerebrospinal fluid (CSF) was obtained from all patients and MCI-AD was defined by means of the t-Tau/A beta(1-42) ratio. Logistic regression analyses tested whether the combination of FCSRT and CERAD-WL measures significantly improved the prediction of MCI-AD. Progression to AD-d was analyzed in a Cox regression model. Results: A total of 202 MCI patients with a mean follow-up of 34.2 +/- 24.2 months were included and 98 (48.5%) met the criteria for MCI-AD. The combination of FCSRT and CERAD-WL measures improved MCI-AD classification accuracy based on CSF biomarkers. Both tests yielded similar global predictive values (59.9-65.3% and 59.4-62.8% for FCSRT and CERAD-WL, respectively). MCI-AD patients with deficits in both FCSRT and CERAD-WL had a faster progression to AD-d than patients with deficits in only one test. Conclusions: The combination of FCSRT and CERAD-WL improves the classification of MCI-AD and defines different prognostic profiles. These findings have important implications for clinical practice and the design of clinical trials.
引用
收藏
页码:909 / 918
页数:10
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