Gut Microbiota and Bone Diseases: A Growing Partnership

被引：39
作者：
Chen, Yu [1 ,2 ]
Wang, Xin [3 ]
Zhang, Chunlei [4 ]
Liu, Zhiyong [3 ]
Li, Chao [3 ]
Ren, Zhigang [1 ,5 ]
机构：
[1] Zhengzhou Univ, Gene Hosp Henan Prov, Precis Med Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Dept Orthopaed Surg, Affiliated Canc Hosp, Zhengzhou, Peoples R China
[4] Zhengzhou Orthopaed Hosp, Bone Tumour & Bone Dis Department2, Zhengzhou, Peoples R China
[5] Zhengzhou Univ, Dept Infect Dis, Affiliated Hosp 1, Zhengzhou, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
gut microbiota; bone diseases; osteoporosis; osteoarthritis; rheumatoid arthritis; bone tumor; CALCIUM-ABSORPTION; DOUBLE-BLIND; T-CELLS; INTESTINAL MICROBIOTA; KNEE OSTEOARTHRITIS; SODIUM-BUTYRATE; MINERAL DENSITY; SUPPLEMENTATION; METABOLISM; HEALTH;
D O I：
10.3389/fmicb.2022.877776
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Gut microbiota is key to human health and disease. Convincing studies have demonstrated that dysbiosis in the commensal gut microbiota is associated with intestinal and extra-intestinal diseases. Recent explorations have significantly contributed to the understanding of the relationship between gut microbiota and bone diseases (osteoporosis, osteoarthritis, rheumatoid arthritis, and bone cancer). Gut microbiota and its metabolites may become associated with the development and progression of bone disorders owing to their critical role in nutrient absorption, immunomodulation, and the gut-brain-bone axis (regulation hormones). In this work, we review the recent developments addressing the effect of gut microbiota modulation on skeletal diseases and explore a feasible preventive approach and therapy for bone diseases.
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页数：14
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