Synthesis and functionalities of poly(N-vinylalkylamide) part XIV -: Synthesis and thermosensitive properties of poly [(N-vinylamide)-co-(vinyl acetate)]s and their hydrogels

被引:53
作者
Yamamoto, K [1 ]
Serizawa, T [1 ]
Akashi, M [1 ]
机构
[1] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostructured & Adv Mat, Kagoshima 8900065, Japan
关键词
coacervate formation; hydrogels; LCST; radical polymerization; thermosensitivity;
D O I
10.1002/macp.200390073
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Free radical copolymerization of water-soluble N-vinylamides such as N-vinylacetamide (NVA) and N-vinylformamide (NVF) with hydrophobic vinyl acetate (VAc) gave amphiphilic copolymers. The monomer reactivity ratios were determined as r(1) = 5.8 and r(2) = 0.68 (M-1 = NVA, M-2 = VAc) and r(1) = 6.2 and r(2) = 0.37 (M-1 = NVF, M-2 = VAc), respectively. The growing radical of the terminals of N-vinylamides propagates more favorably for N-vinylamide monomers than for VAc monomer, resulting in the possible formation of blocky copolymers. It is found that aqueous solutions of these amphiphilic copolymers exhibited a lower critical solution temperature (LCST), depending on their chemical composition, followed by coacervate formation above the LCST. Furthermore, thermosensitive hydrogels could be prepared by the free radical copolymerization of N-vinylamide and VAc in the presence of the crosslinker butylenebis(N-vinylacetamide) (Bis-NVA). The swelling ratios of these hydrogels decreased with an immediate increase in temperature from 20 to 80 degreesC, and then reversibly increased with decreasing temperature. These hydrogels showed the same thermosensitive properties as linear copolymers of NVF and VAc.
引用
收藏
页码:1027 / 1033
页数:7
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