Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker

被引：8
作者：
Wang, Yi-ting [1 ,2 ]
Fan, Shi-rui [1 ,2 ]
Cai, Jie-yun [1 ,3 ]
Guo, Jing-jing [1 ]
Zhang, Xin-fang [1 ,2 ]
Yang, Bi-juan [1 ]
Hao, Xiao-jiang [1 ]
Chen, Duo-zhi [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
[2] Yunnan Univ, Dept Chem Sci & Engn, Kunming, Yunnan, Peoples R China
[3] Yunnan Tobacco Qual Supervis & Test Stn, Kunming, Yunnan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Cytotoxic; cycloartane triterpenoid; Aphanamixis polystachya; LEAVES;
D O I：
10.1080/14786419.2021.1906242
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new cycloartane triterpenoids, (24 R)-cycloartane-3 beta,24,25,30-tetrol (1) and (24 R)-24,25,30-trihydroxy-9,19-cycloartane-3-one (2), along with three known compounds (3-5) were isolated from leaves and twigs of Aphanamixis polystachya. The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound 1 exhibited cytotoxic activity on all of tested human cancer cell lines, while compound 2 only had specific activity on SMMC-7721 cell line.
引用
收藏
页码：2473 / 2478
页数：6
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