Ceftaroline for Severe Methicillin-Resistant Staphylococcus aureus Infections: A Systematic Review

被引：66
作者：
Cosimi, Reese A. [1 ]
Beik, Nahal [2 ]
Kubiak, David W. [3 ]
Johnson, Jennifer A. [4 ,5 ]
机构：
[1] Massachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA
[2] Brigham & Womens Hosp, Ctr Drug Policy Partners Healthcare, 75 Francis St, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Pharm, 75 Francis St, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA
[5] Harvard Med Sch, Cambridge, MA USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 02期
关键词：
ceftaroline; methicillin-resistant Staphylococcus aureus (MRSA); bacteremia; endocarditis; pneumonia; DAPTOMYCIN PLUS CEFTAROLINE; RETROSPECTIVE CASE SERIES; OF-THE-LITERATURE; SALVAGE THERAPY; BETA-LACTAMS; FOSAMIL; BACTEREMIA; ENDOCARDITIS; PNEUMONIA; COMBINATION;
D O I：
10.1093/ofid/ofx084
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ceftaroline is approved by the Food and Drug Administration for acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia, including cases with concurrent bacteremia. Use for serious methicillin-resistant Staphylococcus aureus (MRSA) infections has risen for a multitude of reasons. The aim of this article is to review the literature evaluating clinical outcomes and safety of ceftaroline prescribed for serious MRSA infections. We conducted a literature search in Ovid (Medline) and PubMed for reputable case reports, clinical trials, and reviews focusing on the use of ceftaroline for treatment of MRSA infections. Twenty-two manuscripts published between 2010 and 2016 met inclusion criteria. Mean clinical cure was 74% across 379 patients treated with ceftaroline for severe MRSA infections. Toxicities were infrequent. Ceftaroline treatment resulted in clinical and microbiologic cure for severe MRSA infections. Close monitoring of hematological parameters is necessary with prolonged courses of ceftaroline.
引用
收藏
页数：7
相关论文
共 35 条
[1]   Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective [J].
Alm, Richard A. ;
McLaughlin, Robert E. ;
Kos, Veronica N. ;
Sader, Helio S. ;
Iaconis, Joseph P. ;
Lahiri, Sushmita D. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (08) :2065-2075
[2]  
[Anonymous], 2015, SAF INF CEFT
[3]  
[Anonymous], 2016, TEFL
[4]   Successful use of ceftaroline for the treatment of MRSA meningitis secondary to an infectious complication of lumbar spine surgery [J].
Balouch, Muhammad Adnan ;
Bajwa, Rizma Jalees ;
Hassoun, Ali .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (02) :624-625
[5]   Daptomycin non-susceptible, vancomycin-intermediate Staphylococcus aureus endocarditis treated with ceftaroline and daptomycin: case report and brief review of the literature [J].
Baxi, Sanjiv M. ;
Chan, Dominic ;
Jain, Vivek .
INFECTION, 2015, 43 (06) :751-754
[6]   Adverse Drug Reactions Associated with Ceftaroline Use: A 2-Center Retrospective Cohort [J].
Blumenthal, Kimberly G. ;
Kuhlen, James L., Jr. ;
Weil, Ana A. ;
Varughese, Christy A. ;
Kubiak, David W. ;
Banerji, Aleena ;
Shenoy, Erica S. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2016, 4 (04) :740-746
[7]   Methicillin-resistant Staphylococcus aureus epidural abscess treated with ceftaroline fosamil salvage therapy [J].
Bucheit, John ;
Collins, Rebeccah ;
Joshi, Prajwol .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2014, 71 (02) :110-113
[8]   Large Retrospective Evaluation of the Effectiveness and Safety of Ceftaroline Fosamil Therapy [J].
Casapao, Anthony M. ;
Davis, Susan L. ;
Barr, Viktorija O. ;
Klinker, Kenneth P. ;
Goff, Debra A. ;
Barber, Katie E. ;
Kaye, Keith S. ;
Mynatt, Ryan P. ;
Molloy, Leah M. ;
Pogue, Jason M. ;
Rybak, Michael J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (05) :2541-2546
[9]   Integrated Analysis of CANVAS 1 and 2: Phase 3, Multicenter, Randomized, Double-Blind Studies to Evaluate the Safety and Efficacy of Ceftaroline versus Vancomycin plus Aztreonam in Complicated Skin and Skin-Structure Infection [J].
Corey, G. Ralph ;
Wilcox, Mark ;
Talbot, George H. ;
Friedland, H. David ;
Baculik, Tanya ;
Witherell, Gary W. ;
Critchley, Ian ;
Das, Anita F. ;
Thye, Dirk .
CLINICAL INFECTIOUS DISEASES, 2010, 51 (06) :641-650
[10]   Successful treatment of meticillin-resistant Staphylococcus aureus (MRSA) aortic prosthetic valve endocarditis with prolonged high-dose daptomycin plus ceftaroline therapy [J].
Cunha, Burke A. ;
Gran, Arthur .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2015, 46 (02) :225-226
1234