Comparative in-vitro activity of the new fluoroquinolone trovafloxacin (CP-99,219) against Gram-positive cocci

被引：29
作者：
Coque, TM
Singh, KV
Murray, BE
机构：
[1] UNIV TEXAS,SCH MED,DIV INFECT DIS,DEPT INTERNAL MED,HOUSTON,TX 77030
[2] UNIV TEXAS,SCH MED,DEPT MICROBIOL & MOLEC GENET,HOUSTON,TX 77030
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 37卷 / 05期
关键词：
D O I：
10.1093/jac/37.5.1011
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The in-vitro activities of the new fluoroquinolone trovafloxacin (CP-99,219) and ciprofloxacin were determined against 225 Gram-positive cocci. Trovafloxacin was 4-32 fold more active than ciprofloxacin against staphylococci and streptococci and also showed greater activity against enterococci including vancomycin resistant Enterococcus faecium and Enterococcus faecalis that were highly resistant to aminoglycosides and/or produced beta-lactamase. Trovafloxacin was also bactericidal at 3 mg/L against enterococci except for isolates for which the MICs were greater than or equal to 2 mg/L.
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页码：1011 / 1016
页数：6
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