Tuning of Copper-Catalyzed Multicomponent Reactions toward 3-Functionalized Oxindoles

被引：30

作者：

Cheng, Dong ^{[1
,2
]}

Ling, Fei ^{[1
]}

Zheng, Chenguang ^{[1
]}

Ma, Cheng ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, 20 Yugu Rd, Hangzhou 310027, Peoples R China

[2] Chaohu Univ, Sch Chem & Mat Engn, Chaohu 238000, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

HIGHLY STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; 2+2 CYCLOADDITION; SULFONYL AZIDES; STEREOCONTROLLED SYNTHESIS; TETRASUBSTITUTED OLEFINS; 2-IMINOOXETANE CHEMISTRY; KETENIMINE FORMATION; SELECTIVE SYNTHESIS; TERMINAL ALKYNES;

D O I：

10.1021/acs.orglett.6b00964

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tunable copper-catalyzed azide-alkyne cycloaddition (CuAAC)-initiated multicomponent reaction strategy for the construction of 3-functionalized indolin-2-ones is reported. Upon controlling the ring opening of four-membered O-heterocyclic intermediates, this unique method enables the divergent derivatization of N-protected isatins to give three-component (3-CR) and four-component (4-CR) adducts, respectively.

引用

页码：2435 / 2438

页数：4

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