Role of Olaparib in the Management of Metastatic Castration-Resistant Prostate Cancer: A Japanese Clinician's Perspective

被引：2

作者：

Matsumoto, Takashi ^{[1
]}

Shiota, Masaki ^{[1
,2
]}

Blas, Leandro ^{[1
]}

Eto, Masatoshi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Urol, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

来源：

CANCER MANAGEMENT AND RESEARCH | 2022年 / 14卷

关键词：

olaparib; metastatic castration-resistant prostate cancer; Japanese; BRCA; companion diagnosis; genomic profile; DNA-REPAIR; DEFECTS; BIOLOGY;

D O I：

10.2147/CMAR.S326114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several studies have identified various targetable genomic alterations in prostate cancer, which accumulate during carcinogenesis and cancer progression. Genomic alterations in genes involved in DNA damage repair by homologous recombination repair may predict increased sensitivity to poly-ADP ribose polymerase (PARP) inhibitors. The Phase 3 PROfound trial has shown that treatment with the PARP inhibitor olaparib was associated with an improved radiographic progression-free survival and overall survival among patients with homologous recombination repair-deficient metastatic castration-resistant prostate cancer (mCRPC) after the treatment with androgen receptor targeting therapy, especially in men with BRCA1 or BRCA2 mutation. In Japan, olaparib was approved in December 2020 for the treatment of mCRPC with BRCA1 or BRCA2 mutation. In addition, genetic tests to detect BRCA1 or BRCA2 mutation to select patients who are likely to benefit from olaparib were also approved. This review summarizes the status of olaparib treatment for mCRPC, focusing on the situation in Japan.

引用

页码：2389 / 2397

页数：9

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