Incidence of Malignancies in HIV-Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

被引：51

作者：

Prosperi, M. C. F. ^{[1
]}

Cozzi-Lepri, A. ^{[11
]}

Castagna, A. ^{[4
]}

Mussini, C. ^{[6
]}

Murri, R. ^{[1
]}

Giacometti, A. ^{[7
,8
]}

Torti, C.

Costantini, A. ^{[9
]}

Narciso, P. ^{[2
]}

Ghinelli, F. ^{[10
]}

Antinori, A. ^{[3
]}

Monforte, A. d'Arminio ^{[5
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Clin Malattie Infett, Rome, Italy

[2] Ist Ric & Cura Carattere Sci L Spallanzani, Div 4, Rome, Italy

[3] Ist Nazl Malattie Infett L Spallanzani, Rome, Italy

[4] Osped San Raffaele, Milan, Italy

[5] Univ Milan, Milan, Italy

[6] Policlin Modena, Clin Malattie Infett, Ancona, Italy

[7] Univ Politecn Marche, Clin Malattie Infett, Ancona, Italy

[8] Osped Riuniti Bergamo, Osped Univ, Serv Immunol Clin, Ancona, Italy

[9] Univ Brescia, Clin Malattie Infett & Trop, Brescia, Italy

[10] Arcispedale St Anna, Div Malattie Infett, Ferrara, Italy

[11] UCL, Res Dept Infect & Populat Hlth, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 50卷 / 09期

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; AIDS-DEFINING CANCERS; RISK; IMMUNODEFICIENCY; DISEASES; TRENDS; HAART;

D O I：

10.1086/651688

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and non-ADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 person-years of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM.

引用

页码：1316 / 1321

页数：6

共 26 条

[1] COX REGRESSION-MODEL FOR COUNTING-PROCESSES - A LARGE SAMPLE STUDY [J].

ANDERSEN, PK ;

GILL, RD .

ANNALS OF STATISTICS, 1982, 10 (04) :1100-1120

[2] CD4+count and risk of non-AIDS diseases following initial treatment for HIV infection [J].

Baker, Jason V. ;

Peng, Grace ;

Rapkin, Joshua ;

Abrams, Donald I. ;

Silverberg, Michael J. ;

MacArthur, Rodger D. ;

Cavert, Winston P. ;

Henry, W. Keith ;

Neaton, James D. .

AIDS, 2008, 22 (07) :841-848

[3] Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals [J].

Burgi, A ;

Brodine, S ;

Wegner, S ;

Milazzo, M ;

Wallace, MR ;

Spooner, K ;

Blazes, DL ;

Agan, BK ;

Armstrong, A ;

Fraser, S ;

Crum, NF .

CANCER, 2005, 104 (07) :1505-1511

[4]

Castro K.G., 1993, 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults

[5] Cancer risk in the swiss HIV cohort study: Associations with immunodeficiency, smoking, and highly active antiretroviral therapy [J].

Clifford, GM ;

Polesel, J ;

Rickenbach, M ;

Dal Maso, L ;

Keiser, O ;

Kofler, A ;

Rapiti, E ;

Levi, F ;

Jundt, G ;

Fisch, T ;

Bordoni, A ;

De Weck, D ;

Franceschi, S .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (06) :425-432

[6] Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study [J].

Crum-Cianflone, Nancy ;

Hullsiek, Katherine Huppler ;

Marconi, Vincent ;

Weintrob, Amy ;

Ganesan, Anuradha ;

Barthel, R. Vincent ;

Fraser, Susan ;

Agan, Brian K. ;

Wegner, Scott .

AIDS, 2009, 23 (01) :41-50

[7] Trends in cancer risk among people with AIDS in the United States 1980-2002 [J].

Engels, Eric A. ;

Pfeiffer, Ruth M. ;

Goedert, James J. ;

Virgo, Phillip ;

McNeel, Timothy S. ;

Scoppa, Steven M. ;

Biggar, Robert J. .

AIDS, 2006, 20 (12) :1645-1654

[8] Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients [J].

Herida, M ;

Mary-Krause, M ;

Kaphan, R ;

Cadranel, J ;

Poizot-Martin, I ;

Rabaud, C ;

Plaisance, N ;

Tissot-Dupont, H ;

Boue, F ;

Lang, JM ;

Costagliola, D .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (18) :3447-3453

[9] The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART) in a London clinic [J].

Ives, NJ ;

Gazzard, BG ;

Easterbrook, PJ .

JOURNAL OF INFECTION, 2001, 42 (02) :134-139

[10]

KESSELRING A, 2009, 5 AIDS SOC C HIV PAT

← 1 2 3 →