n-3 polyunsaturated fatty acids and insulin secretion

被引：36
作者：
Wang, Xiaofeng [1 ]
Chan, Catherine B. [1 ]
机构：
[1] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2R3, Canada
来源：
JOURNAL OF ENDOCRINOLOGY | 2015年 / 224卷 / 03期
关键词：
n-3; PUFA; insulin secretion; islets; beta-cells; PANCREATIC BETA-CELLS; ACTIVATED-RECEPTOR-ALPHA; ADIPOSE-TISSUE INFLAMMATION; LIPID RAFTS; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; MESSENGER-RNA; PPAR-ALPHA; ADIPONECTIN RECEPTORS; TRANSGENIC MICE;
D O I：
10.1530/JOE-14-0581
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
n-3 polyunsaturated fatty acids (PUFAs) are a subgroup of fatty acids with broad health benefits, such as lowering blood triglycerides and decreasing the risk of some types of cancer. A beneficial effect of n-3 PUFAs in diabetes is indicated by results from some studies. Defective insulin secretion is a fundamental pathophysiological change in both types 1 and 2 diabetes. Emerging studies have provided evidence of a connection between n-3 PUFAs and improved insulin secretion from pancreatic beta-cells. This review summarizes the recent findings in this regard and discusses the potential mechanisms by which n-3 PUFAs influence insulin secretion from pancreatic beta-cells.
引用
收藏
页码：R97 / R106
页数：10
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