A biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid

被引：26
作者：
Nakagawa, Yoshiyuki [1 ]
Nakasako, Satoshi [2 ]
Ohta, Seiichi [2 ]
Ito, Taichi [1 ,2 ]
机构：
[1] Univ Tokyo, Dept Chem Syst Engn, Bunkyo Ku, Tokyo 1138656, Japan
[2] Univ Tokyo, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan
来源：
CARBOHYDRATE POLYMERS | 2015年 / 117卷
基金：
日本学术振兴会;
关键词：
Hyaluronic acid; Polyacrylic acid; Controlled radical polymerization; Intraperitoneal administration; Drug delivery; Adhesion preventing material; CROSS-LINKING; HYDROGEL; DERIVATIVES; COPOLYMERS; ADHESIONS; GLYCOL); CHAINS; MODEL; ATRP; SIZE;
D O I：
10.1016/j.carbpol.2014.09.037
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We have synthesized hyaluronic acid (HA) grafted with polyacrylic acid (PAA) via controlled radical polymerization (CRP) in aqueous media. The grafted HA (HA-g-PAA) showed slow degradation by hyaluronidase compared with unmodified HA as a result of the steric hindrance produced by grafted PAA, and PAA was detached by hydrolysis and enzymatic degradation by lipase. It formed an insoluble salt immediately after mixing with Ca2+ by the binding between grafted PAA and Ca2+. Both HA-g-PAA and its salt showed good biocompatibility, especially to mesothelial cells in vitro. Finally, they were administered into mice subcutaneously and intraperitoneally. The residue of the material was observed 7 days after subcutaneous administration, while the material was almost cleared from the peritoneum 7 days after intraperitoneal administration with or without Ca2+. HA-g-PAA is expected to be applicable to medical uses such as drug delivery in the peritoneum and for materials preventing peritoneal adhesion. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：43 / 53
页数：11
相关论文
共 57 条
[41]   Synthesis of N-alanyl-hyaluronamide with high degree of substitution for enhanced resistance to hyaluronidase-mediated digestion [J].
Schante, Carole ;
Zuber, Guy ;
Herlin, Corinne ;
Vandamme, Thierry F. .
CARBOHYDRATE POLYMERS, 2011, 86 (02) :747-752
[42]   Improvement of hyaluronic acid enzymatic stability by the grafting of amino-acids [J].
Schante, Carole E. ;
Zuber, Guy ;
Herlin, Corinne ;
Vandamme, Thierry F. .
CARBOHYDRATE POLYMERS, 2012, 87 (03) :2211-2216
[43]   Collapse of sodium polyacrylate chains in calcium salt solutions [J].
Schweins, R ;
Huber, K .
EUROPEAN PHYSICAL JOURNAL E, 2001, 5 (01) :117-126
[44]   A new hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials [J].
Shimizu, Atsushi ;
Suhara, Takashi ;
Ito, Taichi ;
Omichi, Kiyohiko ;
Naruse, Katsutoshi ;
Hasegawa, Kiyoshi ;
Kokudo, Norihiro .
SURGERY TODAY, 2014, 44 (02) :314-323
[45]   Disulfide cross-linked hyaluronan hydrogels [J].
Shu, XZ ;
Liu, YC ;
Luo, Y ;
Roberts, MC ;
Prestwich, GD .
BIOMACROMOLECULES, 2002, 3 (06) :1304-1311
[46]   In situ crosslinkable hyaluronan hydrogels for tissue engineering [J].
Shu, XZ ;
Liu, YC ;
Palumbo, FS ;
Lu, Y ;
Prestwich, GD .
BIOMATERIALS, 2004, 25 (7-8) :1339-1348
[47]   Hyaluronic Acid Viscosupplementation and Osteoarthritis: Current Uses and Future Directions [J].
Strauss, Eric J. ;
Hart, Jennifer A. ;
Miller, Mark D. ;
Altman, Roy D. ;
Rosen, Jeffrey E. .
AMERICAN JOURNAL OF SPORTS MEDICINE, 2009, 37 (08) :1636-1644
[48]   Injectable oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for nucleus pulposus regeneration [J].
Su, Wen-Yu ;
Chen, Yu-Chun ;
Lin, Feng-Huei .
ACTA BIOMATERIALIA, 2010, 6 (08) :3044-3055
[49]   In Situ Cross-Linkable Hydrogel of Hyaluronan Produced via Copper-Free Click Chemistry [J].
Takahashi, Akira ;
Suzuki, Yukimitsu ;
Suhara, Takashi ;
Omichi, Kiyohiko ;
Shimizu, Atsushi ;
Hasegawa, Kiyoshi ;
Kokudo, Norihiro ;
Ohta, Seiichi ;
Ito, Taichi .
BIOMACROMOLECULES, 2013, 14 (10) :3581-3588
[50]   Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering [J].
Tan, Huaping ;
Ramirez, Christina M. ;
Miljkovic, Natasa ;
Li, Han ;
Rubin, J. Peter ;
Marra, Kacey G. .
BIOMATERIALS, 2009, 30 (36) :6844-6853
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