A biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid

被引：26

作者：

Nakagawa, Yoshiyuki ^{[1
]}

Nakasako, Satoshi ^{[2
]}

Ohta, Seiichi ^{[2
]}

Ito, Taichi ^{[1
,2
]}

机构：

[1] Univ Tokyo, Dept Chem Syst Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CARBOHYDRATE POLYMERS | 2015年 / 117卷

基金：

日本学术振兴会;

关键词：

Hyaluronic acid; Polyacrylic acid; Controlled radical polymerization; Intraperitoneal administration; Drug delivery; Adhesion preventing material; CROSS-LINKING; HYDROGEL; DERIVATIVES; COPOLYMERS; ADHESIONS; GLYCOL); CHAINS; MODEL; ATRP; SIZE;

D O I：

10.1016/j.carbpol.2014.09.037

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have synthesized hyaluronic acid (HA) grafted with polyacrylic acid (PAA) via controlled radical polymerization (CRP) in aqueous media. The grafted HA (HA-g-PAA) showed slow degradation by hyaluronidase compared with unmodified HA as a result of the steric hindrance produced by grafted PAA, and PAA was detached by hydrolysis and enzymatic degradation by lipase. It formed an insoluble salt immediately after mixing with Ca2+ by the binding between grafted PAA and Ca2+. Both HA-g-PAA and its salt showed good biocompatibility, especially to mesothelial cells in vitro. Finally, they were administered into mice subcutaneously and intraperitoneally. The residue of the material was observed 7 days after subcutaneous administration, while the material was almost cleared from the peritoneum 7 days after intraperitoneal administration with or without Ca2+. HA-g-PAA is expected to be applicable to medical uses such as drug delivery in the peritoneum and for materials preventing peritoneal adhesion. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：43 / 53

页数：11

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