Novel Pyrazolo[1,5-a]Pyrimidines and Pyrazolo[5,1-c][1,2,4]Triazines Incorporating Indole Moiety as a New Class of Antioxidant Agents

被引:24
作者
El-Mekabaty, Ahmed [1 ]
Fadda, Ahmed A. [1 ]
机构
[1] Mansoura Univ, Fac Sci, Chem Dept, El Gomhoria St, ET-35516 Mansoura, Egypt
关键词
BIOLOGICAL EVALUATION; ANTICANCER AGENTS; PURINE ANALOGS; DERIVATIVES; CHEMISTRY; ANTIBACTERIAL; ALKALOIDS;
D O I
10.1002/jhet.3288
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This effort focuses on the construction of novel pyrazolo[1,5-a]pyrimidines bearing indole nucleus via the reaction of 3-(1H-indol-3-yl)-1H-pyrazol-5-amine (3) with the appropriate reagents or through solvent free condensations with active methylene components and triethyl orthoformate. The utility of (3) for the preparation of pyrazolo[5,1-c][1, 2, 4]triazines was also explored via coupling of diazonium salt of (3) with active methylene compounds. Antioxidant activity screening of the synthetic targets showed that compounds (13), (14), (16), and (17) exhibited a promising activity.
引用
收藏
页码:2303 / 2308
页数:6
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