A comparison of the orexin receptor distribution in the brain between diurnal Nile grass rats (Arvicanthis niloticus) and nocturnal mice (Mus musculus)

被引：21

作者：

Ikeno, Tomoko ^{[1
,3
]}

Yan, Lily ^{[1
,2
]}

机构：

[1] Michigan State Univ, Dept Psychol, 217 Giltner Hall, E Lansing, MI 48824 USA

[2] Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA

[3] Univ Tokyo, Sch Sci, Dept Biol Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

BRAIN RESEARCH | 2018年 / 1690卷

关键词：

Orexin; Hypocretin; Chronotype; OX1R; OX2R; SLEEP-WAKE CYCLE; STRIA TERMINALIS; BED NUCLEUS; SUPRACHIASMATIC NUCLEUS; FOS EXPRESSION; LUTEINIZING-HORMONE; PHASE PREFERENCE; MURID RODENT; LIGHT; ANXIETY;

D O I：

10.1016/j.brainres.2018.04.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide orexin/hypocretin regulates a wide range of behaviors and physiology through its receptors OX1R and OX2R, or HCRTR-1 and HCRTR-2. Although the distributions of these receptors have been established in nocturnal rodents, their distributions in the brain of diurnal species have not been studied. In the present study, we examined spatial patterns of OX1R and OX2R mRNA expression in diurnal Nile grass rats (Arvicanthis niloticus) by in situ hybridization and compared them with those in nocturnal mice (Mus musculus). Both receptors showed similar spatial patterns between species in most brain regions. However, species -specific expression was found in several regions that are mainly implicated in regulation of sleep/wakefulness, emotion and cognition. OX1R expression was detected in the caudate putamen and ventral tuberomammillary nucleus only in grass rats, while it was detected in the bed nucleus of the stria terminalis, medial division, posteromedial part only in mice. The distribution of OX2R mRNA was mostly consistent between the two species, although it was more widely expressed in the ventral tuberomammillary nucleus in grass rats compared to mice. These results suggest that neuronal pathways of the orexin system differ between chronotypes, and these differences could underlie the distinct profiles in behaviors and physiology between diurnal and nocturnal species. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：89 / 95

页数：7

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