Inhibition of phospholipase A2 as a therapeutic target

被引:81
作者
Yedgar, S [1 ]
Lichtenberg, D
Schnitzer, E
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, IL-91120 Jerusalem, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1488卷 / 1-2期
关键词
phospholipase A(2); secretory PLA(2); eicosanoid; inflammatory process; anti-inflammatory drug; inhibition of PLA(2); cell-impermeable PLA(2) inhibitor;
D O I
10.1016/S1388-1981(00)00120-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The hydrolysis of cell membrane phospholipids by phospholipase A(2) (PLA(2)) leads to the production of numerous lipid mediators of diverse pathological conditions, mainly inflammatory diseases. These include lysophospholipids and their derivatives, and arachidonic acid and its derivatives (the eicosanoids). Both these groups of mediators are produced predominantly by the secretory PLA(2)s (sPLA(2)s) which hydrolyze the phospholipids of the cell surface membrane. Protection of cell membrane from these 'inflammatory enzymes' can therefore be used for the treatment of inflammatory processes. A prototype of cell-impermeable PLA(2) inhibitors, which protect the cell membrane from different sPLA(2)s without affecting vital phospholipid metabolism, is presented and discussed in the present review. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:182 / 187
页数:6
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