Arrays of high aspect ratio magnetic microstructures for large trapping throughput in lab-on-chip systems

Here we report a novel technology to obtain arrays of highly efficient magnetic micro-traps that relies on simple fabrication process. Developed micro-traps consist in chains of iron particles diluted in polydimethylsiloxane (PDMS). We analyzed the microstructure of the composite membrane by X-ray tomography. It revealed the predominance of aligned chain-like agglomerates. Largest traps, with diameter ranging from 4 to 11 mu m, are found to be the most efficient. The trap arrays were characterized by a density of 1300 magnetic micro-traps/mm(2), an average nearest neighbor distance of 21 mu m. Implemented in a microfluidic channel operating at a relatively high flow rate of 0.97 mu L/s-a flow velocity of 8.3 mm/s-we measured a trapping efficiency of more than 99.7%, with a throughput of up to 7100 trapped beads/min. These performances are competitive with other approaches like hydrodynamic trapping. The strengths of this technology are its simple fabrication and easy handling.