Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

被引：65

作者：

Chen, Pu ^{[1
]}

Huang, Liuwei ^{[2
]}

Ma, Yufeng ^{[3
]}

Zhang, Dong ^{[1
]}

Zhang, Xiaozhe ^{[1
]}

Zhou, Jun ^{[1
]}

Ruan, Anmin ^{[1
]}

Wang, Qingfu ^{[3
]}

机构：

[1] Beijing Univ Chinese Med, Beijing, Peoples R China

[2] Southern Med Univ, Guangzhou, Guangdong, Peoples R China

[3] Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Orthopaed Surg, 51 XiaoGuan St, Beijing, Peoples R China

来源：

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2019年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Platelet-rich plasma; Knee osteoarthritis; Intra-articular injection; Meta-analysis; Hyaluronic acid; Placebo; GROWTH-FACTORS PRGF; RANDOMIZED CONTROLLED-TRIAL; HYALURONIC-ACID; DOUBLE-BLIND; OUTCOMES; PLACEBO; EPIDEMIOLOGY; EFFICACY; ENDORET; DISEASE;

D O I：

10.1186/s13018-019-1363-y

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective The purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the use of PRP in the treatment of KOA patients, and (3) to highlight gaps in the literature that require future investigation. Material and methods PubMed, EMBASE, and Cochrane databases search were performed for meta-analyses which compared PRP injection with HA or placebo. Clinical outcomes and adverse events were extracted from these meta-analyses. Meta-analysis quality was assessed using the Quality of Reporting of Meta-analyses (QUOROM) systems and the Oxman-Guyatt quality appraisal tool. The Jadad decision algorithm was also used to determine which meta-analysis provided the best available evidence. Results Four meta-analyses were included in our study, and all of these articles were Level I evidence. The QUOROM score of each included meta-analysis range from 14 to 17 points (mean score 15, maximum score 18), and the Oxman-Guyatt score range from 4 to 6 points (mean score 5, maximum score 7). Three meta-analyses indicated PRP showed more benefit in pain relief and functional improvement than the control group, and the other one suggested no difference between these groups. All included meta-analyses found no statistical difference in adverse events between these groups. In addition, a meta-analysis conducted by Shen et al. got the highest methodological quality score and suggested that PRP provided better pain relief and function improvement in the treatment of KOA. Conclusions For short-term follow-up (<= 1 year), intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo, and there is no difference in the risk of an adverse event between PRP and HA or placebo. Trial registration PROSPERO ID CRD42018116168

引用

页数：11

共 56 条

[1] Nonsurgical Treatments of Patellar Tendinopathy: Multiple Injections of Platelet-Rich Plasma Are a Suitable Option: A Systematic Review and Meta-analysis [J].