Now a Nobel gas: oxygen

被引：46

作者：

Fandrey, Joachim ^{[1
]}

Schoedel, Johannes ^{[2
]}

Eckardt, Kai-Uwe ^{[3
]}

Katschinski, Doerthe M. ^{[4
]}

Wenger, Roland H. ^{[5
,6
]}

机构：

[1] Univ Duisburg Essen, Inst Physiol, D-45122 Essen, Germany

[2] Friedrich Alexander Univ Erlangen Nuremberg, Dept Hypertens & Nephrol, D-91054 Erlangen, Germany

[3] Charite Univ Med Berlin, Dept Nephrol & Med Intens Care, D-10117 Berlin, Germany

[4] Georg August Univ, Inst Cardiovasc Physiol, Univ Med Ctr Gottingen, D-37073 Gottingen, Germany

[5] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

[6] Univ Zurich, Natl Ctr Competence Res Kidney CH, CH-8057 Zurich, Switzerland

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2019年 / 471卷 / 11-12期

基金：

瑞士国家科学基金会;

关键词：

Erythropoietin; High altitude; Hypoxia; Oxygen sensing; Protein hydroxylation; von Hippel-Lindau; HYPOXIA-INDUCIBLE FACTOR-1; HUMAN ERYTHROPOIETIN GENE; ENDOTHELIAL GROWTH-FACTOR; FACTOR PROLYL HYDROXYLASE; TUMOR-SUPPRESSOR PROTEIN; GENOME-WIDE IDENTIFICATION; CHRONIC KIDNEY-DISEASE; RENAL-CELL CARCINOMA; HIF-BINDING SITES; TRANSGENIC MICE;

D O I：

10.1007/s00424-019-02334-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The recent bestowal of the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe, and William G. Kaelin Jr. celebrates a series of remarkable discoveries that span from the physiological research question on how oxygen deficiency (hypoxia) induces the red blood cell forming hormone erythropoietin (Epo) to the first clinical application of a novel family of Epo-inducing drugs to treat patients suffering from renal anemia. This review looks back at the most important findings made by the three Nobel laureates, highlights current research trends, and sheds an eye on future perspectives of hypoxia research, including emerging and potential clinical applications.

引用

页码：1343 / 1358

页数：16

共 161 条

[51] HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing [J].

Ivan, M ;

Kondo, K ;

Yang, HF ;

Kim, W ;

Valiando, J ;

Ohh, M ;

Salic, A ;

Asara, JM ;

Lane, WS ;

Kaelin, WG .

SCIENCE, 2001, 292 (5516) :464-468

[52] Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α [J].

Iyer, NV ;

Kotch, LE ;

Agani, F ;

Leung, SW ;

Laughner, E ;

Wenger, RH ;

Gassmann, M ;

Gearhart, JD ;

Lawler, AM ;

Yu, AY ;

Semenza, GL .

GENES & DEVELOPMENT, 1998, 12 (02) :149-162

[53] Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation [J].

Jaakkola, P ;

Mole, DR ;

Tian, YM ;

Wilson, MI ;

Gielbert, J ;

Gaskell, SJ ;

von Kriegsheim, A ;

Hebestreit, HF ;

Mukherji, M ;

Schofield, CJ ;

Maxwell, PH ;

Pugh, CW ;

Ratcliffe, PJ .

SCIENCE, 2001, 292 (5516) :468-472

[54] New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein [J].

Kaelin, William G., Jr. .

TOWARD PERSONALIZED MEDICINE FOR CANCER, 2010, 1210 :1-7

[55] Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway [J].

Kallio, PJ ;

Wilson, WJ ;

O'Brien, S ;

Makino, Y ;

Poellinger, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6519-6525

[56] Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex [J].

Kamura, T ;

Sato, S ;

Iwai, K ;

Czyzyk-Krzeska, M ;

Conaway, RC ;

Conaway, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10430-10435

[57] HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression [J].

Keith, Brian ;

Johnson, Randall S. ;

Simon, M. Celeste .

NATURE REVIEWS CANCER, 2012, 12 (01) :9-22

[58] BINDING OF THE VONHIPPEL-LINDAU TUMOR-SUPPRESSOR PROTEIN TO ELONGIN-B AND ELONGIN-C [J].

KIBEL, A ;

ILIOPOULOS, O ;

DECAPRIO, JA ;

KAELIN, WG .

SCIENCE, 1995, 269 (5229) :1444-1446

[59] Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor [J].

Koditz, Jens ;

Nesper, Jutta ;

Wottawa, Marieke ;

Stiehl, Daniel P. ;

Camenisch, Gieri ;

Franke, Corinna ;

Myllyharju, Johanna ;

Wenger, Roland H. ;

Katschinski, Dorthe M. .

BLOOD, 2007, 110 (10) :3610-3617

[60] Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation [J].

Koivunen, Peppi ;

Lee, Sungwoo ;

Duncan, Christopher G. ;

Lopez, Giselle ;

Lu, Gang ;

Ramkissoon, Shakti ;

Losman, Julie A. ;

Joensuu, Paivi ;

Bergmann, Ulrich ;

Gross, Stefan ;

Travins, Jeremy ;

Weiss, Samuel ;

Looper, Ryan ;

Ligon, Keith L. ;

Verhaak, Roel G. W. ;

Yan, Hai ;

Kaelin, William G., Jr. .

NATURE, 2012, 483 (7390) :485-U144

← 1 2 3 4 5 6 7 8 9 10 →