Does exposure to environmental 2,4-dichlorophenoxyacetic acid concentrations increase mortality rate in animals? A meta-analytic review

被引:18
作者
Da Silva, Ana Paula [1 ]
Morais, Elizete Rodrigues [1 ]
Oliveira, Elton Celton [1 ]
Ghisi, Nedia de Castilhos [2 ]
机构
[1] Univ Tecnol Fed Parana UTFPR, Programa Posgrad Agroecossistemas, Estr Boa Esperanca S-N,Km 04,Caixa Postal 157, BR-85660000 Dois Vizinhos, Para, Brazil
[2] Univ Tecnol Fed Parana UTFPR, Programa Posgrad Biotecnol, Estr Boa Esperanca S-N,Km 04,Caixa Postal 157, BR-85660000 Dois Vizinhos, Para, Brazil
关键词
Herbicide; Mortality; Fish; Toxicity; OXIDATIVE STRESS; CHRONIC TOXICITY; 2,4-D; HERBICIDE; WATER; INVERTEBRATES; FORMULATIONS; POLLUTANTS; SURVIVAL; ESTER;
D O I
10.1016/j.envpol.2022.119179
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The 2,4-dichlorophenoxyacetic acid (2,4-D) is an auxinic herbicide widely used in agriculture that is effective in controlling weeds. It is directly applied to the soil, to ponds or sprayed onto crops; thus, it can progressively accumulate in environmental compartments and affect non-target organisms. The aim of the present meta-analytic review is to investigate the toxic effects of 2,4-D, based on a compilation of results from different studies, which were synthesized to form a statistically reliable conclusion about the lethal effect of potentially ecological concentrations of 2,4-D in several animal species. The search was carried out in the Web of Science and Scopus databases. After the selection process was over, 87 datasets were generated and analyzed. The overall effect has indicated significant increase in the mortality rate recorded for animals exposed to environmental concentrations of 2,4-D compared to the control in the experiment (unexposed animals). The segregation of animals into taxonomic categories has shown that fish and birds presented higher mortality rates after exposure to the investigated substance. The present meta-analysis indicated larval and adult animals were susceptible among the ontogenetic development stages. Juvenile individuals exposed to different 2,4-D concentrations did not show significant difference in comparison to the control. Organisms exposed to 2,4-D immersion were the most impacted compared to those exposed by oral, spray and contact. Animals subjected to commercial formulation presented higher mortality rate than the analytical standard. Thus, 2,4-D can, in fact, increase mortality rate in animals, but it depends on species sensitivity, life stage and exposure route. This is the first meta-analytical study evaluating the mortality rate after 2,4-D exposure in several animal species.
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页数:14
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共 92 条
  • [1] Introduction to systematic review and meta-analysis
    Ahn, EunJin
    Kang, Hyun
    [J]. KOREAN JOURNAL OF ANESTHESIOLOGY, 2018, 71 (02) : 103 - 112
  • [2] Interaction of the 2.4-dichlorophenoxyacetic acid herbicide with soil organic matter moieties: a theoretical study
    Aquino, A. J. A.
    Tunega, D.
    Habephauer, G.
    Gerzabek, M. H.
    Lischka, H.
    [J]. EUROPEAN JOURNAL OF SOIL SCIENCE, 2007, 58 (04) : 889 - 899
  • [3] Oxidative stress as a mechanism for toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D): studies with goldfish gills
    Atamaniuk, Tetiana M.
    Kubrak, Olga I.
    Storey, Kenneth B.
    Lushchak, Volodymyr I.
    [J]. ECOTOXICOLOGY, 2013, 22 (10) : 1498 - 1508
  • [4] Azevedo-Linhares M., 2018, ECOTOX ENVIRON SAFE
  • [5] Response to Letter to the Editor "Is glyphosate toxic to bees? A meta-analytical review"
    Battisti, Lucas
    Potrich, Michele
    Sampaio, Amanda Roberta
    Ghisi, Nedia de Castilhos
    Costa-Maia, Fabiana Martins
    Abati, Raiza
    dos Reis Martinez, Claudia Bueno
    Sofia, Silvia Helena
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 790
  • [6] Borenstein M., 2009, INTRO METANALYSIS, DOI [DOI 10.1002/9780470743386.CH24, https://doi.org/10.1002/9780470743386.ch16, DOI 10.1002/9780470743386.CH16, 10.1002/9780470743386.ch13., DOI 10.1002/9780470743386.CH13]
  • [7] Three-bestseller pesticides in Brazil: Freshwater concentrations and potential environmental risks
    Brovini, Emilia Marques
    Thome de Deus, Beatriz Correa
    Vilas-Boas, Jessica Andrade
    Quadra, Gabrielle Rabelo
    Carvalho, Luana
    Mendonca, Raquel Fernandes
    Pereira, Renata de Oliveira
    Cardoso, Simone Jaqueline
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 771
  • [8] Carraschi Silvia Patricia, 2011, Acta Scientiarum Biological Sciences, V33, P191, DOI 10.4025/actascibiolsci.v33i2.6252
  • [9] Performance of biomarkers metallothionein and ethoxyresorufin O-deethylase in aquatic environments: A meta-analytic approach
    Carrenho Fabrin, Thornaz Mansini
    Diamante, Nathalia Alves
    Mendonca Mota, Thais Fernandes
    Ghisi, Nedia de Castilhos
    Alves Pinto Prioli, Sonia Maria
    Prioli, Alberto Jose
    [J]. CHEMOSPHERE, 2018, 205 : 339 - 349
  • [10] Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents
    Charles, JM
    Bond, DM
    Jeffries, TK
    Yano, BL
    Stott, WT
    Johnson, KA
    Cunny, HC
    Wilson, RD
    Bus, JS
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1996, 33 (02): : 166 - 172