Mapping platypus SOX genes;: autosomal location of SOX9 excludes it from sex determining role

被引：13

作者：

Wallis, M. C. ^{[1
]}

Delbridge, M. L.

Pask, A. J.

Alsop, A. E.

Grutzner, F.

O'Brien, P. C. M.

Rens, W.

Ferguson-Smith, M. A.

Graves, J. A. M.

机构：

[1] Australian Natl Univ, Res Sch Biol Sci, Comparat Genom Grp, Canberra, ACT 2601, Australia

[2] Univ Melbourne, Dept Zool, Melbourne, Vic, Australia

[3] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia

[4] Univ Cambridge, Dept Vet Med, Cambridge Resource Cte Comparat Genom, Cambridge CB2 1TN, England

来源：

CYTOGENETIC AND GENOME RESEARCH | 2007年 / 116卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1159/000098192

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus. Copyright (c) 2007 S. Karger AG, Basel

引用

页码：232 / 234

页数：3

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